| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 98 | 14 | 14 | 6 | 4 | 3.80 | .265 | 1.07 | 8.2 | 1.5 | 8.2 | 92.1 | 84 | 40 | 39 | 13 | 15 | 84 | 1 | 0 | 0 | 0 | 8 | 1 | 2 | 3.53 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 95 | 14 | 14 | 7 | 4 | 4.22 | .316 | 1.37 | 9.9 | 2.6 | 8.0 | 91.2 | 100 | 43 | 43 | 9 | 26 | 81 | 1 | 0 | 0 | 0 | 10 | 1 | 1 | 3.40 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 14 | 14 | 5 | 2 | 4.73 | .308 | 1.30 | 8.4 | 3.3 | 8.8 | 80.0 | 75 | 42 | 42 | 14 | 29 | 78 | 0 | 0 | 0 | 0 | 7 | 3 | 5 | 4.53 |
| SP | Nelson, R.Nelson, Roger $ >> | 28 | 1972 | R | 88 | 13 | 13 | 2 | 5 | 3.18 | .259 | 1.03 | 6.8 | 2.6 | 5.1 | 70.2 | 53 | 25 | 25 | 6 | 20 | 40 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 3.87 |
| SP | Liriano, F.Liriano, Francisco $ >> | 23 | 2006 | L | 74 | 14 | 13 | 4 | 2 | 3.81 | .280 | 1.17 | 8.2 | 2.3 | 9.8 | 59.0 | 54 | 25 | 25 | 3 | 15 | 64 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 2.25 |
| SU | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 93 | 28 | 0 | 0 | 2 | 2.76 | .274 | 1.13 | 5.1 | 5.3 | 9.3 | 32.2 | 18 | 12 | 10 | 0 | 19 | 33 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 2.72 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 33 | 0 | 1 | 1 | 3.86 | .256 | 0.98 | 6.2 | 2.8 | 10.6 | 39.2 | 27 | 19 | 17 | 7 | 12 | 46 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.05 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 32 | 0 | 3 | 1 | 3.18 | .287 | 1.18 | 6.5 | 4.4 | 11.3 | 39.2 | 28 | 14 | 14 | 6 | 19 | 49 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 4.03 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 52 | 8 | 0 | 0 | 0 | 0.00 | .289 | 1.22 | 3.0 | 8.0 | 13.0 | 9.0 | 3 | 0 | 0 | 0 | 8 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.78 |