| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 12 | 12 | 4 | 6 | 4.38 | .283 | 1.16 | 8.1 | 2.4 | 10.8 | 86.1 | 77 | 42 | 42 | 16 | 23 | 103 | 1 | 0 | 0 | 0 | 6 | 2 | 1 | 3.90 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 12 | 12 | 5 | 4 | 3.39 | .275 | 1.12 | 6.8 | 3.3 | 10.4 | 87.2 | 66 | 40 | 33 | 12 | 32 | 101 | 2 | 0 | 0 | 1 | 8 | 2 | 0 | 3.64 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 12 | 12 | 5 | 3 | 3.86 | .329 | 1.43 | 9.2 | 3.8 | 8.7 | 81.2 | 83 | 40 | 35 | 11 | 34 | 78 | 1 | 0 | 0 | 0 | 9 | 3 | 2 | 4.21 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 57 | 11 | 11 | 2 | 9 | 6.45 | .335 | 1.50 | 10.6 | 2.9 | 6.7 | 74.0 | 87 | 55 | 53 | 17 | 24 | 55 | 2 | 0 | 0 | 1 | 2 | 1 | 1 | 5.51 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 32 | 0 | 5 | 0 | 3.29 | .268 | 1.10 | 5.9 | 4.0 | 9.9 | 38.1 | 25 | 14 | 14 | 7 | 17 | 42 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 4.53 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 93 | 24 | 0 | 0 | 2 | 5.96 | .393 | 1.90 | 9.8 | 7.8 | 12.3 | 22.2 | 24 | 15 | 15 | 4 | 19 | 30 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 5.36 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 9 | 0 | 1 | 0 | 2.16 | .242 | 0.84 | 4.5 | 3.4 | 13.5 | 8.1 | 4 | 2 | 2 | 1 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.13 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 66 | 6 | 0 | 1 | 0 | 0.00 | .205 | 0.77 | 4.1 | 3.3 | 3.3 | 11.2 | 5 | 0 | 0 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.36 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 56 | 8 | 0 | 0 | 0 | 6.43 | .344 | 1.57 | 10.3 | 3.9 | 6.4 | 7.0 | 8 | 5 | 5 | 1 | 3 | 5 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.71 |
| SP | Weaver, J.Weaver, Jered >> | 29 | 2011 | R | 54 | 1 | 0 | 0 | 0 | 5.40 | .444 | 2.40 | 12.0 | 12.0 | 6.0 | 3.1 | 4 | 2 | 2 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.67 |