| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 22 | 22 | 10 | 7 | 3.82 | .270 | 1.09 | 7.2 | 2.6 | 8.1 | 158.0 | 127 | 68 | 67 | 20 | 45 | 143 | 4 | 0 | 0 | 0 | 14 | 3 | 5 | 3.75 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 21 | 21 | 6 | 6 | 4.90 | .309 | 1.31 | 8.9 | 2.9 | 9.3 | 128.2 | 127 | 73 | 70 | 28 | 41 | 132 | 1 | 0 | 0 | 0 | 10 | 5 | 3 | 4.86 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 73 | 20 | 20 | 3 | 12 | 5.08 | .323 | 1.39 | 8.6 | 4.0 | 7.2 | 136.1 | 130 | 79 | 77 | 19 | 60 | 109 | 2 | 0 | 0 | 1 | 7 | 5 | 3 | 4.65 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 20 | 20 | 8 | 7 | 5.62 | .311 | 1.34 | 9.9 | 2.2 | 9.4 | 125.0 | 137 | 81 | 78 | 24 | 30 | 131 | 3 | 0 | 0 | 1 | 8 | 2 | 4 | 4.17 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 45 | 0 | 3 | 0 | 3.02 | .248 | 0.95 | 7.3 | 1.4 | 10.4 | 53.2 | 43 | 18 | 18 | 6 | 8 | 61 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.74 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 32 | 0 | 0 | 1 | 2.89 | .211 | 0.80 | 5.1 | 2.2 | 8.8 | 37.1 | 21 | 12 | 12 | 5 | 9 | 36 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 3.54 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 82 | 38 | 0 | 4 | 2 | 2.25 | .284 | 1.19 | 7.7 | 3.0 | 9.6 | 48.0 | 41 | 16 | 12 | 5 | 16 | 51 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.23 |
| CL | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 43 | 0 | 2 | 10 | 6.75 | .333 | 1.43 | 10.6 | 2.4 | 11.6 | 45.1 | 53 | 36 | 34 | 13 | 12 | 58 | 0 | 19 | 5 | 0 | 0 | 3 | 0 | 5.18 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 29 | 0 | 2 | 4 | 4.54 | .285 | 1.19 | 7.1 | 3.9 | 8.5 | 37.2 | 29 | 22 | 19 | 7 | 16 | 35 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.86 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 24 | 0 | 1 | 0 | 3.07 | .273 | 1.09 | 6.2 | 3.7 | 11.8 | 29.1 | 20 | 10 | 10 | 5 | 12 | 38 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 3.97 |