| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 34 | 34 | 10 | 11 | 4.63 | .337 | 1.48 | 10.0 | 3.3 | 8.5 | 213.2 | 237 | 114 | 110 | 32 | 79 | 200 | 1 | 0 | 0 | 0 | 19 | 10 | 6 | 4.33 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 30 | 30 | 8 | 9 | 4.49 | .300 | 1.28 | 8.2 | 3.3 | 5.8 | 164.1 | 149 | 83 | 82 | 20 | 61 | 105 | 0 | 0 | 0 | 0 | 10 | 1 | 5 | 4.44 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 78 | 32 | 32 | 6 | 13 | 6.27 | .343 | 1.54 | 10.1 | 3.8 | 6.2 | 179.1 | 200 | 126 | 125 | 30 | 76 | 123 | 2 | 0 | 0 | 0 | 9 | 5 | 6 | 5.16 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 31 | 31 | 5 | 17 | 7.19 | .363 | 1.68 | 11.1 | 4.1 | 6.0 | 157.2 | 194 | 130 | 126 | 34 | 71 | 104 | 1 | 0 | 0 | 0 | 9 | 5 | 4 | 5.94 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 70 | 0 | 6 | 9 | 3.42 | .263 | 1.03 | 7.2 | 2.2 | 10.7 | 73.2 | 58 | 30 | 28 | 9 | 18 | 87 | 0 | 28 | 5 | 0 | 0 | 3 | 1 | 3.08 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 81 | 73 | 0 | 3 | 2 | 3.67 | .303 | 1.28 | 6.6 | 4.9 | 10.2 | 88.1 | 65 | 36 | 36 | 12 | 48 | 100 | 0 | 0 | 3 | 0 | 0 | 2 | 4 | 4.20 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 75 | 0 | 8 | 2 | 4.00 | .311 | 1.33 | 7.3 | 4.7 | 9.7 | 90.0 | 73 | 42 | 40 | 13 | 47 | 97 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 4.36 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 66 | 63 | 0 | 6 | 1 | 2.47 | .253 | 0.99 | 6.8 | 2.3 | 6.8 | 76.2 | 57 | 24 | 21 | 9 | 19 | 57 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.87 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 55 | 39 | 0 | 1 | 3 | 3.83 | .323 | 1.41 | 9.4 | 3.5 | 9.4 | 44.2 | 46 | 20 | 19 | 3 | 17 | 46 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 3.02 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 64 | 10 | 2 | 0 | 0 | 7.07 | .382 | 1.79 | 12.2 | 3.9 | 5.5 | 28.0 | 38 | 22 | 22 | 4 | 12 | 17 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 5.14 |