| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 94 | 22 | 22 | 9 | 6 | 3.62 | .304 | 1.29 | 7.4 | 4.2 | 8.9 | 139.1 | 115 | 57 | 56 | 15 | 65 | 138 | 1 | 0 | 0 | 1 | 16 | 3 | 0 | 3.88 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 90 | 21 | 21 | 14 | 4 | 2.97 | .261 | 1.03 | 7.4 | 1.9 | 6.8 | 160.2 | 131 | 55 | 53 | 14 | 34 | 120 | 6 | 0 | 0 | 0 | 14 | 5 | 1 | 3.37 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 55 | 21 | 21 | 7 | 9 | 5.37 | .353 | 1.60 | 9.7 | 4.7 | 8.3 | 122.1 | 132 | 79 | 73 | 17 | 64 | 113 | 0 | 0 | 0 | 0 | 9 | 4 | 3 | 4.63 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 43 | 0 | 2 | 6 | 5.18 | .321 | 1.37 | 7.7 | 4.8 | 8.8 | 41.2 | 35 | 24 | 24 | 8 | 22 | 40 | 0 | 25 | 5 | 0 | 0 | 2 | 0 | 5.34 |
| RP | Brewer, J.Brewer, Jim † >> | 35 | 1972 | L | 70 | 59 | 0 | 6 | 1 | 2.90 | .314 | 1.34 | 7.7 | 4.4 | 8.5 | 83.2 | 71 | 28 | 27 | 9 | 41 | 78 | 0 | 4 | 2 | 0 | 0 | 3 | 2 | 4.12 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 70 | 44 | 0 | 2 | 2 | 3.18 | .270 | 1.08 | 6.9 | 2.9 | 10.1 | 56.2 | 43 | 20 | 20 | 6 | 18 | 63 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 3.21 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 65 | 33 | 0 | 1 | 3 | 4.76 | .315 | 1.35 | 9.5 | 2.6 | 10.1 | 34.0 | 36 | 18 | 18 | 9 | 10 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.18 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 64 | 19 | 0 | 2 | 0 | 4.66 | .341 | 1.55 | 9.5 | 4.7 | 9.5 | 19.1 | 20 | 10 | 10 | 2 | 10 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.84 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 68 | 11 | 0 | 0 | 0 | 4.50 | .268 | 1.10 | 6.3 | 3.6 | 5.4 | 10.0 | 7 | 5 | 5 | 2 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.60 |