| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 35 | 35 | 17 | 12 | 3.42 | .279 | 1.11 | 6.9 | 3.2 | 9.5 | 239.2 | 182 | 97 | 91 | 34 | 85 | 253 | 2 | 0 | 0 | 1 | 25 | 11 | 2 | 3.94 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 31 | 31 | 14 | 9 | 4.90 | .326 | 1.42 | 9.7 | 3.1 | 6.8 | 196.2 | 212 | 112 | 107 | 33 | 68 | 149 | 1 | 0 | 0 | 0 | 17 | 5 | 1 | 4.79 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 95 | 72 | 0 | 5 | 8 | 2.72 | .274 | 1.12 | 6.3 | 3.9 | 10.6 | 79.1 | 55 | 24 | 24 | 5 | 34 | 93 | 0 | 38 | 2 | 0 | 0 | 1 | 4 | 2.80 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 78 | 86 | 0 | 5 | 2 | 3.75 | .314 | 1.34 | 7.3 | 4.8 | 9.1 | 108.0 | 87 | 48 | 45 | 13 | 58 | 109 | 0 | 5 | 5 | 0 | 0 | 3 | 0 | 4.24 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 81 | 0 | 6 | 3 | 3.75 | .296 | 1.25 | 7.5 | 3.9 | 8.9 | 93.2 | 77 | 41 | 39 | 16 | 40 | 92 | 0 | 2 | 5 | 0 | 0 | 1 | 1 | 4.58 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 48 | 0 | 1 | 1 | 1.70 | .296 | 1.23 | 6.6 | 4.4 | 10.5 | 53.0 | 39 | 14 | 10 | 3 | 26 | 62 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 2.98 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 60 | 13 | 0 | 2 | 1 | 5.03 | .338 | 1.47 | 10.3 | 2.9 | 9.5 | 34.0 | 39 | 19 | 19 | 4 | 11 | 36 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.56 |