| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 38 | 38 | 16 | 13 | 3.98 | .311 | 1.29 | 7.7 | 3.9 | 9.3 | 242.0 | 207 | 110 | 107 | 22 | 105 | 249 | 0 | 0 | 0 | 0 | 26 | 15 | 4 | 3.61 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 36 | 36 | 16 | 11 | 3.90 | .296 | 1.23 | 7.8 | 3.3 | 8.6 | 221.2 | 191 | 100 | 96 | 28 | 81 | 210 | 1 | 0 | 0 | 0 | 21 | 8 | 4 | 3.95 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 96 | 0 | 4 | 2 | 2.80 | .259 | 1.02 | 7.2 | 2.0 | 9.1 | 122.0 | 97 | 43 | 38 | 13 | 27 | 124 | 0 | 1 | 2 | 0 | 0 | 4 | 0 | 3.11 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 78 | 0 | 10 | 12 | 3.75 | .238 | 0.93 | 6.6 | 1.8 | 8.6 | 86.1 | 63 | 38 | 36 | 11 | 17 | 82 | 0 | 38 | 6 | 0 | 0 | 1 | 2 | 3.38 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 71 | 0 | 6 | 1 | 3.24 | .279 | 1.12 | 6.6 | 3.5 | 8.9 | 86.0 | 63 | 35 | 31 | 8 | 33 | 85 | 0 | 1 | 2 | 0 | 0 | 4 | 0 | 3.52 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 62 | 0 | 1 | 3 | 3.34 | .253 | 1.00 | 5.9 | 3.3 | 9.6 | 72.2 | 47 | 27 | 27 | 6 | 26 | 77 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 3.07 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 53 | 14 | 4 | 6 | 1 | 4.57 | .356 | 1.64 | 8.2 | 6.7 | 7.5 | 43.1 | 39 | 25 | 22 | 6 | 32 | 36 | 0 | 1 | 1 | 0 | 2 | 1 | 1 | 5.44 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 51 | 0 | 3 | 4 | 4.79 | .305 | 1.30 | 7.1 | 4.6 | 10.0 | 47.0 | 37 | 25 | 25 | 11 | 24 | 52 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 5.43 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 87 | 72 | 0 | 0 | 3 | 3.93 | .287 | 1.17 | 7.1 | 3.4 | 9.3 | 68.2 | 54 | 31 | 30 | 8 | 26 | 70 | 0 | 6 | 7 | 0 | 0 | 3 | 1 | 3.75 |