| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 34 | 34 | 22 | 8 | 2.31 | .239 | 0.92 | 6.3 | 2.0 | 9.4 | 221.2 | 155 | 59 | 57 | 17 | 50 | 231 | 1 | 0 | 0 | 0 | 29 | 4 | 0 | 2.64 |
| SP | Buehler, W.Buehler, Walker † # >> | 23 | 2018 | R | 84 | 33 | 33 | 19 | 7 | 2.69 | .266 | 1.07 | 6.4 | 3.3 | 8.1 | 201.0 | 143 | 61 | 60 | 16 | 73 | 182 | 1 | 0 | 0 | 1 | 22 | 3 | 7 | 3.36 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 32 | 32 | 14 | 5 | 3.32 | .286 | 1.15 | 6.5 | 3.9 | 8.5 | 195.0 | 141 | 75 | 72 | 22 | 84 | 185 | 0 | 0 | 0 | 0 | 20 | 9 | 3 | 4.00 |
| SP | Harvey, M.Harvey, Matt # >> | 24 | 2013 | R | 76 | 31 | 31 | 12 | 9 | 4.60 | .302 | 1.27 | 9.1 | 2.4 | 8.7 | 180.0 | 181 | 100 | 92 | 26 | 47 | 173 | 3 | 0 | 0 | 2 | 15 | 6 | 3 | 3.84 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 52 | 0 | 1 | 1 | 2.40 | .290 | 1.17 | 5.8 | 4.8 | 11.4 | 56.1 | 36 | 15 | 15 | 10 | 30 | 71 | 0 | 2 | 0 | 0 | 0 | 3 | 4 | 4.55 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 70 | 50 | 0 | 3 | 1 | 3.71 | .281 | 1.12 | 7.7 | 2.6 | 9.6 | 60.2 | 51 | 25 | 25 | 8 | 17 | 64 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 3.60 |
| SU | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 84 | 0 | 3 | 3 | 2.65 | .236 | 0.91 | 5.4 | 2.8 | 10.2 | 98.1 | 59 | 30 | 29 | 10 | 30 | 111 | 0 | 3 | 7 | 0 | 0 | 2 | 4 | 3.04 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 77 | 0 | 4 | 7 | 2.12 | .227 | 0.84 | 5.9 | 1.8 | 10.4 | 80.2 | 52 | 20 | 19 | 9 | 16 | 92 | 0 | 47 | 3 | 0 | 0 | 3 | 1 | 2.88 |