| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 95 | 35 | 35 | 18 | 9 | 3.17 | .266 | 1.06 | 6.8 | 2.8 | 9.0 | 238.1 | 179 | 88 | 84 | 27 | 74 | 238 | 3 | 0 | 0 | 0 | 24 | 6 | 5 | 3.48 |
| SP | Flaherty, J.Flaherty, Jack # >> | 23 | 2019 | R | 83 | 33 | 33 | 13 | 12 | 4.75 | .309 | 1.29 | 8.6 | 3.0 | 9.0 | 193.1 | 185 | 104 | 102 | 31 | 65 | 194 | 0 | 0 | 0 | 0 | 17 | 9 | 8 | 4.23 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 32 | 32 | 4 | 15 | 6.14 | .340 | 1.50 | 8.9 | 4.7 | 8.0 | 136.1 | 134 | 98 | 93 | 21 | 71 | 121 | 0 | 0 | 0 | 0 | 0 | 6 | 8 | 4.93 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 60 | 0 | 2 | 3 | 2.48 | .249 | 0.92 | 6.6 | 1.7 | 10.7 | 65.1 | 48 | 19 | 18 | 9 | 12 | 77 | 0 | 37 | 2 | 0 | 0 | 5 | 2 | 3.22 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 79 | 81 | 0 | 4 | 4 | 2.97 | .288 | 1.18 | 6.5 | 4.1 | 8.2 | 94.0 | 68 | 31 | 31 | 9 | 43 | 86 | 0 | 1 | 3 | 0 | 0 | 3 | 3 | 3.88 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 57 | 0 | 2 | 2 | 3.38 | .275 | 1.14 | 4.8 | 5.5 | 9.8 | 64.0 | 34 | 25 | 24 | 7 | 39 | 70 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 4.06 |