| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 16 | 16 | 3 | 8 | 7.13 | .360 | 1.66 | 11.5 | 3.5 | 8.3 | 77.0 | 98 | 62 | 61 | 13 | 30 | 71 | 1 | 0 | 0 | 0 | 5 | 2 | 3 | 4.60 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 2 | 7 | 6.13 | .339 | 1.50 | 10.7 | 2.8 | 9.2 | 79.1 | 94 | 60 | 54 | 18 | 25 | 81 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 4.97 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 15 | 15 | 4 | 6 | 7.13 | .347 | 1.60 | 12.3 | 2.1 | 7.9 | 72.0 | 98 | 58 | 57 | 15 | 17 | 63 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 4.67 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 43 | 0 | 0 | 7 | 4.91 | .341 | 1.53 | 8.6 | 5.4 | 10.7 | 47.2 | 45 | 26 | 26 | 6 | 28 | 56 | 0 | 14 | 1 | 0 | 0 | 1 | 3 | 4.13 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 48 | 0 | 2 | 3 | 3.19 | .294 | 1.23 | 7.6 | 3.6 | 10.2 | 53.2 | 45 | 22 | 19 | 8 | 21 | 60 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.94 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 43 | 0 | 4 | 2 | 3.50 | .316 | 1.35 | 8.2 | 4.0 | 8.8 | 54.0 | 49 | 23 | 21 | 7 | 24 | 53 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 4.17 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 46 | 0 | 0 | 2 | 5.76 | .336 | 1.46 | 8.6 | 4.5 | 10.4 | 50.0 | 48 | 34 | 32 | 5 | 25 | 58 | 0 | 0 | 0 | 0 | 0 | 3 | 6 | 3.66 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 42 | 0 | 4 | 1 | 3.14 | .320 | 1.34 | 9.2 | 3.0 | 8.8 | 51.2 | 52 | 19 | 18 | 1 | 17 | 50 | 0 | 0 | 2 | 0 | 0 | 4 | 0 | 2.53 |