| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 16 | 16 | 10 | 1 | 2.91 | .283 | 1.18 | 7.0 | 3.6 | 8.2 | 102.0 | 79 | 33 | 33 | 4 | 41 | 93 | 1 | 0 | 0 | 1 | 11 | 1 | 4 | 2.92 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 15 | 15 | 5 | 6 | 4.58 | .286 | 1.20 | 9.2 | 1.7 | 5.6 | 92.1 | 94 | 52 | 47 | 12 | 17 | 57 | 2 | 0 | 0 | 0 | 6 | 0 | 2 | 4.01 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 15 | 15 | 3 | 7 | 5.03 | .301 | 1.28 | 9.4 | 2.2 | 5.6 | 91.1 | 95 | 55 | 51 | 13 | 22 | 57 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 4.36 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 15 | 15 | 3 | 5 | 4.63 | .334 | 1.51 | 8.1 | 5.5 | 7.4 | 83.2 | 75 | 44 | 43 | 9 | 51 | 68 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 4.61 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 14 | 14 | 10 | 2 | 3.40 | .304 | 1.27 | 7.8 | 3.6 | 4.9 | 90.0 | 78 | 36 | 34 | 8 | 36 | 49 | 0 | 0 | 0 | 0 | 10 | 4 | 2 | 4.40 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 41 | 0 | 3 | 2 | 4.24 | .301 | 1.27 | 9.0 | 2.5 | 8.5 | 51.0 | 51 | 24 | 24 | 3 | 14 | 48 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 2.76 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 30 | 0 | 4 | 1 | 4.05 | .291 | 1.23 | 9.0 | 2.2 | 8.7 | 33.1 | 33 | 19 | 15 | 6 | 8 | 32 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.15 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 21 | 0 | 2 | 2 | 3.42 | .290 | 1.23 | 5.9 | 5.5 | 7.8 | 23.2 | 15 | 11 | 9 | 0 | 14 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.09 |
| CL | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 29 | 0 | 2 | 2 | 1.41 | .248 | 0.99 | 6.4 | 2.6 | 9.0 | 38.1 | 27 | 9 | 6 | 0 | 11 | 38 | 0 | 15 | 2 | 0 | 0 | 0 | 4 | 1.87 |