| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 32 | 32 | 19 | 9 | 2.92 | .284 | 1.18 | 8.1 | 2.5 | 7.9 | 243.1 | 219 | 88 | 79 | 27 | 67 | 212 | 9 | 0 | 0 | 2 | 21 | 3 | 8 | 3.56 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 31 | 31 | 19 | 9 | 4.97 | .329 | 1.46 | 9.4 | 3.8 | 8.8 | 192.0 | 201 | 109 | 106 | 25 | 80 | 187 | 0 | 0 | 0 | 0 | 16 | 2 | 3 | 4.03 |
| SP | Guidry, R.Guidry, Ron † # >> | 28 | 1978 | L | 77 | 31 | 31 | 22 | 5 | 3.43 | .266 | 1.06 | 6.9 | 2.6 | 5.3 | 247.0 | 189 | 95 | 94 | 28 | 72 | 146 | 17 | 0 | 0 | 3 | 19 | 7 | 2 | 4.25 |
| SP | Sutton, D.Sutton, Don † >> | 27 | 1972 | R | 82 | 30 | 30 | 14 | 10 | 3.58 | .291 | 1.23 | 8.0 | 3.0 | 4.8 | 231.0 | 205 | 102 | 92 | 23 | 78 | 123 | 10 | 0 | 0 | 4 | 18 | 2 | 4 | 4.27 |
| RP | Doolittle, S.Doolittle, Sean $ >> | 31 | 2018 | L | 99 | 63 | 0 | 3 | 4 | 2.35 | .238 | 0.94 | 6.8 | 1.8 | 8.0 | 72.2 | 54 | 20 | 19 | 8 | 14 | 64 | 0 | 11 | 3 | 0 | 0 | 0 | 4 | 3.25 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 13 | 0 | 0 | 1 | 2.03 | .259 | 1.05 | 6.2 | 3.5 | 8.3 | 13.1 | 9 | 3 | 3 | 2 | 5 | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 12 | 0 | 1 | 1 | 2.45 | .283 | 1.18 | 5.7 | 4.9 | 6.5 | 11.0 | 7 | 3 | 3 | 0 | 6 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.18 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 16 | 0 | 1 | 0 | 3.44 | .276 | 1.15 | 7.0 | 3.5 | 7.0 | 18.1 | 14 | 7 | 7 | 2 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.06 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 14 | 0 | 6 | 3 | 3.98 | .299 | 1.25 | 8.4 | 2.8 | 5.6 | 61.0 | 57 | 27 | 27 | 8 | 19 | 38 | 0 | 1 | 0 | 0 | 0 | 2 | 8 | 4.49 |