| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 32 | 32 | 11 | 15 | 4.11 | .302 | 1.27 | 7.6 | 3.9 | 8.9 | 227.2 | 192 | 105 | 104 | 32 | 98 | 225 | 5 | 0 | 0 | 1 | 19 | 6 | 6 | 4.22 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 31 | 31 | 12 | 10 | 4.21 | .292 | 1.23 | 8.3 | 2.8 | 7.8 | 209.1 | 193 | 100 | 98 | 24 | 65 | 181 | 2 | 0 | 0 | 0 | 22 | 1 | 4 | 3.71 |
| SP | Greinke, Z.Greinke, Zack † >> | 32 | 2015 | R | 94 | 29 | 29 | 13 | 11 | 3.77 | .288 | 1.21 | 8.6 | 2.4 | 5.6 | 214.2 | 204 | 95 | 90 | 30 | 56 | 132 | 8 | 0 | 0 | 1 | 18 | 1 | 8 | 4.39 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 49 | 0 | 0 | 4 | 3.09 | .296 | 1.24 | 6.5 | 4.8 | 7.3 | 43.2 | 31 | 15 | 15 | 2 | 23 | 35 | 0 | 43 | 4 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 46 | 0 | 4 | 5 | 1.90 | .277 | 1.14 | 8.0 | 2.4 | 5.3 | 61.2 | 54 | 20 | 13 | 4 | 16 | 36 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 3.51 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 18 | 0 | 2 | 1 | 4.63 | .286 | 1.20 | 8.6 | 2.3 | 9.4 | 23.1 | 22 | 12 | 12 | 4 | 6 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.96 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 14 | 0 | 1 | 0 | 4.28 | .311 | 1.34 | 9.3 | 2.8 | 7.3 | 54.2 | 56 | 26 | 26 | 5 | 17 | 44 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.57 |