| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 36 | 36 | 7 | 17 | 4.72 | .335 | 1.49 | 8.1 | 5.3 | 7.3 | 215.1 | 194 | 126 | 113 | 12 | 126 | 174 | 2 | 0 | 0 | 1 | 18 | 5 | 4 | 3.93 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 34 | 34 | 15 | 11 | 4.11 | .315 | 1.35 | 8.3 | 3.9 | 8.1 | 223.1 | 205 | 106 | 102 | 10 | 97 | 200 | 2 | 0 | 0 | 0 | 22 | 6 | 3 | 3.17 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 82 | 33 | 33 | 17 | 9 | 3.51 | .290 | 1.21 | 8.7 | 2.2 | 4.5 | 225.1 | 218 | 97 | 88 | 27 | 55 | 113 | 4 | 0 | 0 | 2 | 20 | 3 | 2 | 4.33 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 92 | 0 | 9 | 5 | 4.63 | .299 | 1.26 | 9.9 | 1.5 | 6.9 | 114.2 | 126 | 60 | 59 | 12 | 19 | 88 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.38 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 79 | 0 | 1 | 4 | 4.43 | .337 | 1.49 | 9.0 | 4.4 | 9.7 | 85.1 | 85 | 45 | 42 | 12 | 42 | 92 | 0 | 3 | 9 | 0 | 0 | 3 | 3 | 4.26 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 59 | 0 | 1 | 1 | 4.04 | .314 | 1.38 | 7.6 | 4.9 | 10.3 | 64.2 | 54 | 32 | 29 | 6 | 35 | 73 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 43 | 0 | 4 | 1 | 2.86 | .327 | 1.39 | 7.0 | 5.5 | 6.8 | 44.0 | 34 | 16 | 14 | 6 | 27 | 33 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.32 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 31 | 29 | 11 | 7 | 4.93 | .317 | 1.39 | 9.3 | 3.2 | 5.6 | 175.1 | 180 | 112 | 96 | 18 | 63 | 109 | 3 | 0 | 0 | 0 | 14 | 1 | 4 | 4.19 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 20 | 2 | 4 | 3 | 6.05 | .337 | 1.50 | 9.2 | 4.5 | 8.8 | 38.2 | 39 | 26 | 26 | 7 | 19 | 37 | 0 | 2 | 2 | 0 | 0 | 1 | 2 | 5.03 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 69 | 0 | 7 | 6 | 3.13 | .260 | 1.06 | 6.4 | 3.1 | 9.6 | 72.0 | 51 | 27 | 25 | 5 | 25 | 77 | 0 | 33 | 7 | 0 | 0 | 0 | 1 | 2.81 |