| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 29 | 29 | 9 | 11 | 3.64 | .297 | 1.25 | 8.3 | 3.0 | 5.5 | 197.2 | 182 | 91 | 80 | 20 | 66 | 121 | 6 | 0 | 0 | 2 | 16 | 3 | 0 | 4.14 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 27 | 27 | 8 | 11 | 4.73 | .327 | 1.44 | 8.0 | 5.0 | 4.8 | 160.0 | 143 | 95 | 84 | 15 | 88 | 86 | 0 | 0 | 0 | 0 | 13 | 2 | 5 | 4.83 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 26 | 25 | 13 | 9 | 4.11 | .296 | 1.23 | 7.9 | 3.2 | 7.9 | 171.0 | 151 | 81 | 78 | 22 | 60 | 151 | 2 | 0 | 0 | 0 | 15 | 5 | 4 | 4.05 |
| RP | Bautista, F.Bautista, Félix # >> | 28 | 2023 | R | 75 | 57 | 0 | 4 | 1 | 3.86 | .292 | 1.24 | 6.5 | 4.7 | 10.8 | 65.1 | 47 | 33 | 28 | 12 | 34 | 78 | 0 | 1 | 2 | 0 | 0 | 0 | 7 | 4.57 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 50 | 0 | 2 | 2 | 5.36 | .373 | 1.77 | 10.8 | 5.2 | 7.4 | 50.1 | 60 | 33 | 30 | 6 | 29 | 41 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.72 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 43 | 0 | 3 | 0 | 1.68 | .291 | 1.21 | 6.5 | 4.6 | 9.2 | 53.2 | 38 | 19 | 10 | 0 | 27 | 54 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2.55 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 66 | 0 | 8 | 6 | 3.09 | .277 | 1.12 | 7.1 | 3.0 | 9.9 | 67.0 | 53 | 28 | 23 | 5 | 22 | 74 | 0 | 27 | 3 | 0 | 0 | 2 | 3 | 2.84 |