| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 82 | 21 | 21 | 10 | 5 | 3.85 | .277 | 1.13 | 8.7 | 1.5 | 4.7 | 154.1 | 149 | 68 | 66 | 17 | 25 | 81 | 5 | 0 | 0 | 3 | 12 | 3 | 0 | 3.93 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 21 | 21 | 9 | 8 | 4.78 | .307 | 1.32 | 9.5 | 2.4 | 3.6 | 145.0 | 153 | 81 | 77 | 17 | 38 | 58 | 6 | 0 | 0 | 1 | 10 | 2 | 3 | 4.55 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 20 | 20 | 10 | 5 | 4.63 | .334 | 1.50 | 9.4 | 4.1 | 4.6 | 128.1 | 133 | 72 | 66 | 16 | 59 | 66 | 4 | 0 | 0 | 0 | 10 | 1 | 2 | 5.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 20 | 19 | 3 | 8 | 4.86 | .331 | 1.44 | 9.3 | 3.8 | 8.8 | 79.2 | 82 | 48 | 43 | 7 | 33 | 77 | 0 | 0 | 0 | 0 | 1 | 3 | 5 | 3.57 |
| RP | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 95 | 55 | 0 | 8 | 0 | 2.83 | .273 | 1.13 | 7.1 | 3.1 | 8.1 | 76.1 | 60 | 25 | 24 | 8 | 26 | 68 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.61 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 44 | 0 | 1 | 2 | 4.05 | .322 | 1.39 | 8.7 | 3.9 | 9.7 | 53.1 | 51 | 27 | 24 | 8 | 23 | 57 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 4.23 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 46 | 0 | 1 | 4 | 4.06 | .294 | 1.23 | 8.5 | 2.7 | 8.7 | 57.2 | 54 | 27 | 26 | 7 | 17 | 55 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.61 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 25 | 0 | 2 | 0 | 4.45 | .320 | 1.41 | 9.3 | 3.5 | 7.4 | 28.1 | 29 | 14 | 14 | 3 | 11 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.93 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 56 | 16 | 1 | 2 | 3 | 12.15 | .420 | 2.10 | 15.6 | 3.8 | 3.1 | 26.2 | 45 | 36 | 36 | 8 | 11 | 9 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 7.81 |