| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 21 | 21 | 7 | 9 | 3.89 | .294 | 1.24 | 8.4 | 2.8 | 7.7 | 157.1 | 147 | 75 | 68 | 15 | 48 | 134 | 8 | 0 | 0 | 3 | 13 | 2 | 6 | 3.49 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 20 | 20 | 11 | 2 | 2.20 | .268 | 1.09 | 7.9 | 1.9 | 4.2 | 159.2 | 140 | 44 | 39 | 13 | 34 | 74 | 4 | 0 | 0 | 0 | 17 | 1 | 4 | 3.79 |
| SP | Clemens, R.Clemens, Roger † # >> | 24 | 1986 | R | 69 | 20 | 20 | 11 | 5 | 3.33 | .288 | 1.20 | 8.0 | 2.8 | 5.9 | 159.1 | 141 | 67 | 59 | 14 | 50 | 105 | 10 | 0 | 0 | 1 | 13 | 2 | 1 | 3.81 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 49 | 0 | 3 | 6 | 4.98 | .325 | 1.43 | 8.2 | 4.7 | 7.6 | 56.0 | 51 | 32 | 31 | 8 | 29 | 47 | 0 | 8 | 5 | 0 | 0 | 1 | 3 | 4.79 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 38 | 0 | 2 | 3 | 5.77 | .368 | 1.69 | 11.8 | 3.5 | 9.5 | 39.0 | 51 | 25 | 25 | 5 | 15 | 41 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 3.87 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 25 | 0 | 2 | 5 | 2.59 | .223 | 0.86 | 7.0 | 0.9 | 5.5 | 31.1 | 24 | 9 | 9 | 3 | 3 | 19 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 3.32 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 52 | 6 | 0 | 1 | 0 | 1.74 | .114 | 0.39 | 1.8 | 1.8 | 11.7 | 10.1 | 2 | 2 | 2 | 2 | 2 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.60 |