| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 22 | 22 | 4 | 8 | 4.05 | .306 | 1.31 | 9.4 | 2.4 | 6.6 | 142.1 | 148 | 77 | 64 | 19 | 38 | 104 | 2 | 0 | 0 | 0 | 13 | 2 | 2 | 4.12 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 22 | 22 | 7 | 11 | 4.73 | .319 | 1.37 | 9.2 | 3.2 | 4.2 | 152.1 | 155 | 90 | 80 | 13 | 54 | 71 | 2 | 0 | 0 | 0 | 7 | 5 | 5 | 4.34 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 19 | 19 | 6 | 7 | 4.77 | .342 | 1.52 | 10.1 | 3.6 | 6.6 | 126.1 | 142 | 74 | 67 | 17 | 50 | 92 | 1 | 0 | 0 | 0 | 10 | 5 | 4 | 4.60 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 20 | 20 | 5 | 11 | 5.64 | .340 | 1.50 | 9.9 | 3.7 | 6.7 | 127.2 | 140 | 82 | 80 | 25 | 52 | 94 | 1 | 0 | 0 | 0 | 6 | 5 | 6 | 5.43 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 51 | 0 | 3 | 1 | 2.49 | .270 | 1.11 | 6.5 | 3.5 | 9.7 | 65.0 | 47 | 22 | 18 | 4 | 25 | 70 | 0 | 3 | 2 | 0 | 0 | 0 | 3 | 2.80 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 53 | 0 | 7 | 0 | 2.76 | .307 | 1.31 | 7.1 | 4.8 | 10.6 | 58.2 | 46 | 18 | 18 | 6 | 31 | 68 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 3.66 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 39 | 0 | 4 | 0 | 1.94 | .256 | 0.98 | 6.1 | 2.9 | 7.0 | 41.2 | 28 | 11 | 9 | 1 | 13 | 32 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 2.85 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 36 | 0 | 2 | 7 | 5.63 | .343 | 1.54 | 9.5 | 4.5 | 9.5 | 38.1 | 40 | 25 | 24 | 3 | 19 | 40 | 0 | 12 | 4 | 0 | 0 | 1 | 0 | 3.50 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 29 | 0 | 4 | 2 | 4.88 | .336 | 1.45 | 9.3 | 4.0 | 9.3 | 27.2 | 28 | 15 | 15 | 2 | 12 | 28 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.44 |