| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 22 | 22 | 9 | 6 | 3.07 | .272 | 1.12 | 7.5 | 2.6 | 9.2 | 164.1 | 136 | 56 | 56 | 18 | 48 | 167 | 2 | 0 | 0 | 1 | 17 | 0 | 2 | 3.27 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 21 | 21 | 6 | 12 | 4.80 | .307 | 1.33 | 9.1 | 2.9 | 8.3 | 135.0 | 136 | 75 | 72 | 16 | 43 | 124 | 1 | 0 | 0 | 0 | 11 | 0 | 3 | 3.66 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 21 | 21 | 8 | 4 | 4.53 | .331 | 1.46 | 9.6 | 3.6 | 4.9 | 105.1 | 112 | 60 | 53 | 16 | 42 | 57 | 0 | 0 | 0 | 0 | 3 | 2 | 2 | 5.15 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 20 | 20 | 7 | 9 | 5.16 | .324 | 1.44 | 9.7 | 3.3 | 5.9 | 144.2 | 155 | 89 | 83 | 20 | 53 | 94 | 6 | 0 | 0 | 0 | 7 | 0 | 2 | 4.60 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 20 | 20 | 6 | 10 | 4.53 | .316 | 1.36 | 9.3 | 2.9 | 4.7 | 143.0 | 148 | 74 | 72 | 12 | 46 | 75 | 6 | 0 | 0 | 0 | 8 | 4 | 4 | 4.09 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 54 | 0 | 4 | 4 | 5.82 | .349 | 1.56 | 9.0 | 5.1 | 9.0 | 60.1 | 60 | 40 | 39 | 6 | 34 | 60 | 0 | 2 | 3 | 0 | 0 | 3 | 3 | 4.15 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 44 | 0 | 3 | 1 | 3.91 | .249 | 0.95 | 5.4 | 3.2 | 9.8 | 48.1 | 29 | 22 | 21 | 5 | 17 | 52 | 0 | 3 | 1 | 0 | 0 | 2 | 2 | 3.38 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 34 | 0 | 1 | 1 | 3.05 | .253 | 0.97 | 6.2 | 2.6 | 7.1 | 38.1 | 26 | 13 | 13 | 5 | 11 | 30 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.16 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 26 | 0 | 3 | 0 | 4.37 | .299 | 1.28 | 7.4 | 4.5 | 7.0 | 22.2 | 18 | 11 | 11 | 3 | 11 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.73 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 19 | 0 | 1 | 0 | 2.22 | .215 | 0.78 | 5.6 | 1.5 | 3.4 | 24.1 | 15 | 7 | 6 | 1 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.42 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 36 | 0 | 3 | 6 | 3.32 | .287 | 1.18 | 6.5 | 4.3 | 7.7 | 40.2 | 29 | 16 | 15 | 6 | 19 | 34 | 0 | 20 | 2 | 0 | 0 | 1 | 0 | 4.75 |