| SP | Buchholz, C.Buchholz, Clay >> | 29 | 2013 | R | 87 | 12 | 12 | 5 | 3 | 4.48 | .311 | 1.32 | 7.9 | 4.1 | 6.1 | 80.1 | 70 | 45 | 40 | 10 | 36 | 54 | 1 | 0 | 0 | 1 | 7 | 3 | 0 | 4.74 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 27 | 2007 | R | 18 | 12 | 12 | 6 | 2 | 3.45 | .325 | 1.42 | 9.3 | 3.5 | 7.4 | 78.1 | 81 | 32 | 30 | 5 | 30 | 64 | 0 | 0 | 0 | 0 | 9 | 2 | 3 | 3.42 |
| SP | Lester, J.Lester, Jon # >> | 29 | 2013 | L | 14 | 12 | 12 | 2 | 5 | 8.74 | .365 | 1.72 | 12.1 | 3.6 | 7.0 | 58.2 | 78 | 57 | 57 | 16 | 23 | 45 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 6.22 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 30 | 2018 | R | 88 | 34 | 0 | 3 | 2 | 4.76 | .328 | 1.39 | 6.9 | 5.8 | 9.7 | 39.2 | 30 | 25 | 21 | 4 | 25 | 42 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 4.33 |
| RP | Barnes, M.Barnes, Matt >> | 28 | 2018 | R | 40 | 30 | 0 | 2 | 2 | 5.52 | .405 | 1.98 | 9.9 | 8.1 | 9.9 | 29.1 | 32 | 19 | 18 | 5 | 26 | 32 | 0 | 0 | 1 | 0 | 0 | 2 | 6 | 5.93 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 98 | 27 | 0 | 0 | 2 | 3.14 | .239 | 0.91 | 5.5 | 2.9 | 10.0 | 28.2 | 17 | 10 | 10 | 3 | 9 | 31 | 0 | 10 | 2 | 0 | 0 | 1 | 0 | 3.25 |
| SU | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 26 | 0 | 2 | 1 | 2.30 | .282 | 1.15 | 7.8 | 2.6 | 10.7 | 31.1 | 27 | 8 | 8 | 2 | 9 | 37 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 2.42 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 40 | 1 | 0 | 0 | 0 | 54.00 | .714 | 7.50 | - | - | - | 0.2 | 4 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Schilling, C.Schilling, Curt >> | 41 | 2007 | R | 10 | 11 | 0 | 3 | 2 | 3.00 | .308 | 1.30 | 8.5 | 3.3 | 5.5 | 33.0 | 31 | 15 | 11 | 4 | 12 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.55 |