| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 83 | 12 | 12 | 6 | 2 | 4.27 | .320 | 1.41 | 8.7 | 4.0 | 8.4 | 78.0 | 75 | 39 | 37 | 6 | 35 | 73 | 0 | 0 | 0 | 0 | 6 | 0 | 2 | 3.47 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 82 | 12 | 12 | 7 | 1 | 3.32 | .308 | 1.32 | 8.3 | 3.7 | 8.2 | 78.2 | 72 | 31 | 29 | 2 | 32 | 71 | 0 | 0 | 0 | 0 | 9 | 1 | 3 | 2.78 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 77 | 12 | 12 | 2 | 6 | 6.81 | .325 | 1.40 | 9.9 | 2.7 | 8.0 | 70.0 | 77 | 53 | 53 | 17 | 21 | 62 | 1 | 0 | 0 | 0 | 3 | 3 | 1 | 5.41 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 58 | 12 | 12 | 8 | 1 | 3.55 | .322 | 1.40 | 7.3 | 5.4 | 8.4 | 78.2 | 63 | 32 | 31 | 5 | 47 | 73 | 1 | 0 | 0 | 0 | 7 | 2 | 3 | 3.85 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 25 | 13 | 12 | 2 | 5 | 6.06 | .365 | 1.71 | 11.1 | 4.4 | 7.0 | 68.1 | 84 | 49 | 46 | 14 | 33 | 53 | 0 | 0 | 0 | 0 | 3 | 1 | 4 | 5.62 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 66 | 29 | 0 | 4 | 2 | 2.18 | .322 | 1.36 | 8.7 | 3.5 | 10.9 | 33.0 | 32 | 8 | 8 | 1 | 13 | 40 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2.33 |
| SU | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 96 | 34 | 0 | 0 | 1 | 2.02 | .327 | 1.46 | 7.2 | 6.2 | 9.8 | 35.2 | 28 | 8 | 8 | 1 | 24 | 38 | 0 | 1 | 2 | 0 | 0 | 0 | 7 | 3.26 |
| CL | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 99 | 32 | 0 | 2 | 1 | 1.53 | .237 | 0.93 | 5.1 | 3.3 | 11.6 | 35.1 | 20 | 7 | 6 | 3 | 13 | 45 | 0 | 17 | 3 | 0 | 0 | 0 | 2 | 2.66 |