| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 92 | 27 | 27 | 8 | 10 | 4.78 | .322 | 1.40 | 9.9 | 2.7 | 6.8 | 148.2 | 163 | 85 | 79 | 24 | 45 | 112 | 0 | 0 | 0 | 0 | 13 | 4 | 3 | 4.59 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 90 | 28 | 28 | 12 | 6 | 4.16 | .326 | 1.42 | 7.4 | 5.4 | 9.1 | 149.1 | 122 | 72 | 69 | 16 | 90 | 151 | 0 | 0 | 0 | 0 | 13 | 5 | 3 | 4.28 |
| SP | Lester, J.Lester, Jon # >> | 32 | 2016 | L | 85 | 27 | 27 | 7 | 15 | 6.16 | .328 | 1.45 | 10.1 | 3.0 | 7.3 | 141.2 | 158 | 99 | 97 | 29 | 47 | 114 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 5.10 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 80 | 27 | 27 | 10 | 8 | 4.35 | .322 | 1.41 | 8.4 | 4.3 | 7.0 | 155.0 | 145 | 75 | 75 | 18 | 74 | 121 | 0 | 0 | 0 | 0 | 17 | 2 | 10 | 4.42 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 77 | 26 | 24 | 10 | 11 | 4.93 | .315 | 1.37 | 8.4 | 3.9 | 8.1 | 146.0 | 136 | 82 | 80 | 25 | 64 | 132 | 0 | 0 | 0 | 0 | 8 | 1 | 3 | 4.75 |
| RP | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 97 | 72 | 0 | 6 | 2 | 3.12 | .299 | 1.26 | 6.6 | 4.8 | 10.3 | 112.2 | 82 | 42 | 39 | 6 | 60 | 128 | 0 | 5 | 0 | 0 | 0 | 2 | 11 | 3.07 |
| RP | Strop, P.Strop, Pedro # >> | 31 | 2016 | R | 92 | 61 | 0 | 6 | 4 | 4.17 | .266 | 1.07 | 6.6 | 3.0 | 9.9 | 101.1 | 74 | 47 | 47 | 15 | 34 | 111 | 0 | 8 | 3 | 0 | 0 | 2 | 5 | 3.80 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 93 | 60 | 0 | 6 | 0 | 3.96 | .310 | 1.32 | 6.2 | 5.7 | 8.4 | 77.1 | 53 | 38 | 34 | 11 | 49 | 72 | 0 | 12 | 6 | 0 | 0 | 2 | 4 | 4.97 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 47 | 0 | 3 | 2 | 2.14 | .262 | 1.05 | 5.3 | 4.1 | 9.9 | 63.0 | 37 | 18 | 15 | 5 | 29 | 69 | 0 | 6 | 3 | 0 | 0 | 1 | 3 | 3.27 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 69 | 43 | 0 | 3 | 1 | 3.92 | .324 | 1.37 | 9.6 | 2.8 | 11.9 | 62.0 | 66 | 27 | 27 | 14 | 19 | 82 | 0 | 2 | 1 | 0 | 0 | 4 | 3 | 4.40 |