| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 15 | 15 | 4 | 8 | 4.68 | .316 | 1.35 | 8.8 | 3.4 | 7.5 | 90.1 | 88 | 48 | 47 | 7 | 34 | 75 | 2 | 0 | 0 | 0 | 8 | 3 | 4 | 3.58 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 15 | 15 | 6 | 6 | 3.98 | .346 | 1.56 | 9.3 | 4.9 | 7.3 | 92.2 | 95 | 43 | 41 | 7 | 50 | 75 | 2 | 0 | 0 | 0 | 10 | 2 | 3 | 4.05 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 42 | 15 | 15 | 3 | 6 | 5.49 | .360 | 1.64 | 10.2 | 4.7 | 8.3 | 78.2 | 88 | 52 | 48 | 9 | 41 | 72 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 4.38 |
| SP | Lieber, J.Lieber, Jon # >> | 31 | 2001 | R | 30 | 15 | 14 | 8 | 5 | 4.56 | .283 | 1.15 | 8.6 | 1.8 | 6.5 | 94.2 | 90 | 49 | 48 | 15 | 19 | 68 | 2 | 0 | 0 | 0 | 6 | 3 | 1 | 4.33 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 40 | 0 | 1 | 1 | 3.81 | .319 | 1.35 | 9.0 | 3.1 | 8.3 | 52.0 | 52 | 25 | 22 | 9 | 18 | 48 | 0 | 4 | 1 | 0 | 0 | 3 | 0 | 4.62 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 74 | 40 | 0 | 1 | 0 | 3.66 | .258 | 1.05 | 6.2 | 3.4 | 9.9 | 51.2 | 35 | 22 | 21 | 8 | 19 | 56 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.96 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 56 | 28 | 0 | 3 | 2 | 3.82 | .312 | 1.36 | 7.7 | 4.6 | 5.9 | 35.1 | 30 | 15 | 15 | 4 | 18 | 23 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 4.71 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 39 | 25 | 0 | 0 | 3 | 3.45 | .239 | 0.94 | 6.1 | 2.6 | 10.3 | 28.2 | 19 | 11 | 11 | 2 | 8 | 32 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.50 |
| RP | Aceves, A.Aceves, Alfredo >> | 27 | 2009 | R | 28 | 16 | 0 | 1 | 2 | 3.00 | .270 | 1.07 | 7.0 | 2.7 | 8.3 | 27.0 | 21 | 10 | 9 | 1 | 8 | 25 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.63 |