| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 29 | 29 | 9 | 13 | 5.61 | .346 | 1.56 | 9.1 | 5.0 | 8.2 | 157.1 | 158 | 105 | 98 | 18 | 88 | 143 | 1 | 0 | 0 | 1 | 10 | 4 | 4 | 4.43 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 28 | 28 | 6 | 12 | 5.96 | .359 | 1.62 | 11.1 | 3.5 | 6.6 | 157.0 | 194 | 105 | 104 | 25 | 61 | 115 | 0 | 0 | 0 | 0 | 10 | 9 | 2 | 4.94 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 53 | 27 | 27 | 5 | 12 | 7.53 | .360 | 1.67 | 11.9 | 3.3 | 7.4 | 132.2 | 174 | 111 | 111 | 36 | 48 | 108 | 0 | 0 | 0 | 0 | 10 | 2 | 4 | 6.05 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 50 | 27 | 27 | 8 | 10 | 5.66 | .337 | 1.50 | 10.6 | 2.9 | 6.9 | 148.0 | 175 | 97 | 93 | 37 | 47 | 114 | 0 | 0 | 0 | 0 | 12 | 4 | 4 | 5.74 |
| SP | Kazmir, S.Kazmir, Scott # >> | 24 | 2008 | L | 40 | 27 | 27 | 8 | 9 | 5.91 | .362 | 1.66 | 10.0 | 5.0 | 9.2 | 140.0 | 155 | 92 | 92 | 27 | 78 | 143 | 0 | 0 | 0 | 0 | 8 | 5 | 4 | 5.24 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 75 | 0 | 6 | 1 | 4.49 | .333 | 1.48 | 9.6 | 3.7 | 11.0 | 106.1 | 113 | 54 | 53 | 11 | 44 | 129 | 0 | 4 | 6 | 0 | 0 | 2 | 0 | 3.22 |
| RP | Valverde, J.Valverde, Jose # >> | 24 | 2003 | R | 79 | 75 | 0 | 1 | 7 | 5.40 | .337 | 1.50 | 8.4 | 5.3 | 9.5 | 101.2 | 94 | 61 | 61 | 15 | 59 | 107 | 0 | 3 | 3 | 0 | 0 | 2 | 6 | 4.62 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 58 | 0 | 4 | 6 | 4.05 | .310 | 1.35 | 7.6 | 4.6 | 6.8 | 73.1 | 62 | 36 | 33 | 12 | 37 | 55 | 0 | 5 | 2 | 0 | 0 | 0 | 2 | 5.15 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 37 | 51 | 0 | 1 | 5 | 3.84 | .285 | 1.20 | 6.4 | 4.5 | 9.5 | 72.2 | 51 | 31 | 31 | 12 | 36 | 76 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 4.56 |
| SP | Washburn, J.Washburn, Jarrod >> | 28 | 2002 | L | 33 | 29 | 0 | 4 | 5 | 8.45 | .411 | 2.04 | 14.0 | 4.6 | 7.6 | 59.2 | 92 | 61 | 56 | 14 | 30 | 50 | 0 | 1 | 3 | 0 | 0 | 3 | 1 | 6.07 |