| SP | Martinez, P.Martinez, Pedro $$ >> | 29 | 2000 | R | 100 | 15 | 15 | 7 | 5 | 4.01 | .292 | 1.23 | 9.2 | 1.9 | 10.0 | 103.1 | 105 | 50 | 46 | 17 | 22 | 114 | 1 | 0 | 0 | 0 | 8 | 1 | 2 | 3.60 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 82 | 15 | 15 | 5 | 3 | 4.05 | .313 | 1.34 | 8.8 | 3.3 | 10.2 | 73.1 | 71 | 36 | 33 | 8 | 27 | 83 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 3.34 |
| SP | Greinke, Z.Greinke, Zack # >> | 26 | 2009 | R | 77 | 15 | 15 | 8 | 5 | 5.40 | .318 | 1.36 | 9.0 | 3.3 | 8.6 | 85.0 | 85 | 53 | 51 | 8 | 31 | 81 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 3.52 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 14 | 14 | 4 | 6 | 5.90 | .339 | 1.46 | 10.9 | 2.2 | 4.7 | 61.0 | 74 | 43 | 40 | 16 | 15 | 32 | 0 | 0 | 0 | 0 | 4 | 5 | 0 | 6.34 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 25 | 0 | 0 | 1 | 2.55 | .245 | 0.93 | 7.5 | 1.1 | 9.8 | 24.2 | 20 | 7 | 7 | 3 | 3 | 26 | 0 | 16 | 2 | 0 | 0 | 1 | 0 | 2.96 |
| SU | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 25 | 0 | 2 | 1 | 3.38 | .321 | 1.38 | 6.8 | 5.6 | 9.4 | 24.0 | 18 | 9 | 9 | 0 | 15 | 25 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 2.92 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 37 | 0 | 2 | 2 | 1.55 | .266 | 1.07 | 6.2 | 3.5 | 7.6 | 52.1 | 36 | 11 | 9 | 4 | 20 | 44 | 0 | 1 | 3 | 0 | 0 | 1 | 2 | 3.52 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 29 | 0 | 1 | 1 | 0.91 | .239 | 0.88 | 6.2 | 1.9 | 7.8 | 29.2 | 20 | 3 | 3 | 0 | 6 | 25 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2.10 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 21 | 0 | 2 | 0 | 1.33 | .229 | 0.81 | 5.3 | 2.0 | 6.0 | 27.0 | 16 | 4 | 4 | 0 | 6 | 18 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2.56 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 38 | 0 | 1 | 1 | 4.85 | .336 | 1.52 | 9.0 | 5.0 | 10.6 | 29.2 | 29 | 18 | 16 | 6 | 16 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.00 |