| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 30 | 30 | 11 | 9 | 4.48 | .321 | 1.36 | 8.7 | 3.6 | 6.2 | 189.0 | 182 | 96 | 94 | 16 | 75 | 131 | 4 | 0 | 0 | 1 | 17 | 11 | 2 | 4.08 |
| SP | Perez, O.Perez, Odalis # >> | 25 | 2002 | L | 82 | 28 | 28 | 8 | 10 | 4.57 | .295 | 1.23 | 9.1 | 2.0 | 6.5 | 181.1 | 183 | 97 | 92 | 35 | 40 | 131 | 2 | 0 | 0 | 0 | 14 | 5 | 3 | 4.81 |
| SP | Carpenter, C.Carpenter, Chris † >> | 34 | 2009 | R | 81 | 28 | 28 | 14 | 10 | 3.31 | .288 | 1.20 | 8.3 | 2.6 | 6.2 | 187.1 | 172 | 69 | 69 | 20 | 53 | 129 | 7 | 0 | 0 | 3 | 18 | 2 | 3 | 3.89 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 27 | 27 | 6 | 9 | 6.43 | .313 | 1.32 | 9.5 | 2.4 | 6.0 | 134.1 | 141 | 97 | 96 | 30 | 36 | 89 | 4 | 0 | 0 | 1 | 7 | 7 | 0 | 5.54 |
| RP | Nathan, J.Nathan, Joe † >> | 32 | 2006 | R | 98 | 73 | 0 | 7 | 2 | 2.99 | .284 | 1.16 | 7.2 | 3.3 | 11.7 | 93.1 | 74 | 33 | 31 | 4 | 34 | 121 | 0 | 6 | 0 | 0 | 0 | 3 | 7 | 2.15 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 64 | 0 | 8 | 4 | 4.09 | .337 | 1.47 | 8.1 | 5.3 | 9.8 | 72.2 | 65 | 39 | 33 | 5 | 42 | 78 | 0 | 7 | 6 | 0 | 0 | 4 | 0 | 3.65 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 48 | 46 | 0 | 2 | 1 | 4.12 | .322 | 1.39 | 9.3 | 3.3 | 7.7 | 54.2 | 56 | 26 | 25 | 9 | 20 | 46 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 4.69 |
| RP | Zumaya, J.Zumaya, Joel # >> | 22 | 2006 | R | 37 | 41 | 0 | 5 | 2 | 4.13 | .332 | 1.45 | 8.3 | 4.8 | 11.4 | 52.1 | 48 | 24 | 24 | 9 | 28 | 66 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 4.44 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 48 | 7 | 0 | 0 | 1 | 3.00 | .321 | 1.42 | 12.8 | 0.0 | 4.5 | 12.0 | 17 | 4 | 4 | 1 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.08 |
| SP | Appier, K.Appier, Kevin >> | 34 | 2001 | R | 37 | 29 | 0 | 1 | 5 | 5.47 | .378 | 1.80 | 10.5 | 5.8 | 6.0 | 54.1 | 63 | 38 | 33 | 11 | 35 | 36 | 0 | 6 | 1 | 0 | 0 | 1 | 3 | 6.31 |