| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 16 | 16 | 3 | 8 | 4.67 | .306 | 1.30 | 9.5 | 2.2 | 9.6 | 108.0 | 114 | 56 | 56 | 19 | 26 | 115 | 3 | 0 | 0 | 0 | 8 | 3 | 4 | 3.96 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 15 | 15 | 5 | 6 | 4.19 | .338 | 1.51 | 9.8 | 3.8 | 9.8 | 86.0 | 94 | 43 | 40 | 12 | 36 | 94 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 3.95 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 15 | 15 | 5 | 5 | 3.47 | .319 | 1.38 | 9.9 | 2.4 | 6.5 | 96.0 | 106 | 38 | 37 | 8 | 26 | 69 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 3.55 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 15 | 15 | 3 | 5 | 5.25 | .316 | 1.38 | 9.8 | 2.6 | 7.2 | 85.2 | 93 | 52 | 50 | 15 | 25 | 68 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 4.61 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 15 | 15 | 7 | 5 | 5.28 | .325 | 1.41 | 10.1 | 2.7 | 7.8 | 88.2 | 99 | 55 | 52 | 15 | 26 | 76 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 4.48 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 46 | 0 | 1 | 0 | 4.47 | .281 | 1.15 | 7.7 | 2.7 | 8.2 | 56.1 | 48 | 31 | 28 | 10 | 17 | 51 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.46 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 85 | 42 | 0 | 3 | 5 | 5.44 | .320 | 1.41 | 9.4 | 3.5 | 8.4 | 44.2 | 46 | 27 | 27 | 6 | 17 | 41 | 0 | 2 | 3 | 0 | 0 | 0 | 2 | 4.07 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 72 | 35 | 0 | 2 | 3 | 4.50 | .325 | 1.38 | 9.0 | 3.4 | 9.5 | 34.0 | 34 | 18 | 17 | 4 | 13 | 36 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.74 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 60 | 20 | 0 | 4 | 2 | 1.93 | .195 | 0.73 | 4.3 | 2.3 | 10.2 | 23.1 | 11 | 7 | 5 | 1 | 6 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.09 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 49 | 0 | 1 | 1 | 2.28 | .259 | 1.01 | 6.3 | 3.0 | 9.7 | 27.2 | 19 | 7 | 7 | 3 | 9 | 29 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 3.41 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 11 | 0 | 0 | 0 | 3.86 | .263 | 1.07 | 7.0 | 3.0 | 10.0 | 9.1 | 7 | 4 | 4 | 1 | 3 | 10 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.22 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 7 | 0 | 0 | 0 | 0.00 | .297 | 1.15 | 9.0 | 2.3 | 7.9 | 8.2 | 8 | 0 | 0 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.38 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 13 | 0 | 1 | 1 | 2.60 | .278 | 1.15 | 6.9 | 3.7 | 12.7 | 17.1 | 13 | 5 | 5 | 2 | 7 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.94 |