| SP | Johnson, R.Johnson, Randy † >> | 38 | 2001 | L | 97 | 29 | 29 | 16 | 6 | 3.10 | .271 | 1.09 | 6.5 | 3.3 | 9.9 | 209.1 | 152 | 78 | 72 | 11 | 76 | 230 | 7 | 0 | 0 | 2 | 20 | 5 | 4 | 2.65 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 27 | 27 | 10 | 8 | 4.67 | .330 | 1.45 | 9.9 | 3.2 | 6.3 | 125.1 | 137 | 66 | 65 | 12 | 45 | 88 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 3.99 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 68 | 28 | 27 | 11 | 8 | 4.13 | .293 | 1.20 | 8.2 | 2.6 | 6.0 | 154.2 | 141 | 72 | 71 | 19 | 45 | 102 | 1 | 0 | 0 | 1 | 13 | 6 | 1 | 4.27 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 84 | 26 | 10 | 10 | 4 | 3.33 | .269 | 1.05 | 7.2 | 2.3 | 6.3 | 105.1 | 84 | 47 | 39 | 14 | 27 | 73 | 4 | 1 | 0 | 1 | 7 | 5 | 2 | 4.26 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 67 | 0 | 3 | 12 | 5.15 | .300 | 1.24 | 8.4 | 2.9 | 9.1 | 71.2 | 66 | 42 | 41 | 11 | 23 | 72 | 0 | 25 | 7 | 0 | 0 | 3 | 2 | 4.08 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 72 | 0 | 4 | 5 | 4.05 | .302 | 1.30 | 8.7 | 3.0 | 6.5 | 80.0 | 77 | 37 | 36 | 12 | 27 | 58 | 0 | 2 | 10 | 0 | 0 | 0 | 3 | 4.51 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 64 | 75 | 0 | 4 | 3 | 3.35 | .292 | 1.22 | 8.7 | 2.4 | 8.9 | 83.1 | 80 | 33 | 31 | 12 | 22 | 82 | 0 | 2 | 3 | 0 | 0 | 1 | 3 | 3.73 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 53 | 58 | 0 | 3 | 1 | 4.32 | .319 | 1.34 | 7.9 | 4.2 | 8.8 | 58.1 | 51 | 28 | 28 | 10 | 27 | 57 | 0 | 2 | 0 | 0 | 0 | 4 | 1 | 4.88 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 50 | 26 | 17 | 8 | 3 | 5.35 | .337 | 1.50 | 10.5 | 3.1 | 7.3 | 109.1 | 127 | 71 | 65 | 20 | 37 | 89 | 0 | 2 | 0 | 0 | 8 | 3 | 1 | 4.85 |