| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 16 | 16 | 1 | 9 | 8.33 | .402 | 1.98 | 11.3 | 6.6 | 5.2 | 71.1 | 89 | 67 | 66 | 15 | 52 | 41 | 1 | 0 | 0 | 1 | 3 | 3 | 3 | 6.92 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 15 | 15 | 2 | 6 | 8.37 | .387 | 1.81 | 13.5 | 2.9 | 7.4 | 62.1 | 93 | 58 | 58 | 20 | 20 | 51 | 0 | 0 | 0 | 0 | 3 | 5 | 1 | 6.76 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 14 | 14 | 3 | 8 | 5.71 | .339 | 1.51 | 10.9 | 2.7 | 6.6 | 82.0 | 99 | 56 | 52 | 11 | 25 | 60 | 1 | 0 | 0 | 0 | 6 | 2 | 3 | 4.27 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 42 | 0 | 5 | 2 | 3.69 | .274 | 1.10 | 7.2 | 2.7 | 9.1 | 61.0 | 49 | 26 | 25 | 12 | 18 | 62 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 4.51 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 73 | 41 | 0 | 1 | 2 | 5.30 | .318 | 1.40 | 9.2 | 3.5 | 8.5 | 54.1 | 55 | 32 | 32 | 8 | 21 | 51 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 4.20 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 47 | 34 | 0 | 1 | 1 | 3.92 | .319 | 1.38 | 8.1 | 4.4 | 8.6 | 41.1 | 37 | 18 | 18 | 9 | 20 | 39 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 5.49 |
| RP | Aceves, A.Aceves, Alfredo >> | 27 | 2009 | R | 30 | 35 | 0 | 4 | 2 | 3.68 | .246 | 0.95 | 6.5 | 2.0 | 6.3 | 44.0 | 32 | 18 | 18 | 5 | 10 | 31 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.82 |
| RP | Benoit, J.Benoit, Joaquin >> | 30 | 2007 | R | 19 | 25 | 0 | 2 | 4 | 6.67 | .356 | 1.59 | 10.3 | 4.2 | 8.0 | 28.1 | 32 | 24 | 21 | 7 | 13 | 25 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 6.07 |
| RP | Graves, D.Graves, Danny >> | 29 | 2002 | R | 1 | 21 | 0 | 1 | 0 | 6.17 | .402 | 1.93 | 13.3 | 4.3 | 5.5 | 23.1 | 34 | 18 | 16 | 1 | 11 | 14 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.04 |
| SP | Wainwright, A.Wainwright, Adam >> | 28 | 2009 | R | 20 | 4 | 0 | 1 | 0 | 4.50 | .308 | 1.33 | 9.0 | 3.0 | 9.0 | 6.0 | 6 | 3 | 3 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.00 |