| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 30 | 30 | 16 | 12 | 3.56 | .283 | 1.15 | 8.4 | 2.0 | 10.9 | 204.2 | 191 | 83 | 81 | 23 | 45 | 246 | 2 | 0 | 0 | 1 | 18 | 6 | 3 | 2.80 |
| SP | Rasmussen, D.Rasmussen, Drew # >> | 29 | 2025 | R | 85 | 29 | 29 | 11 | 7 | 3.80 | .297 | 1.23 | 8.7 | 2.4 | 8.4 | 156.1 | 151 | 68 | 66 | 21 | 42 | 145 | 0 | 0 | 0 | 0 | 9 | 5 | 1 | 3.79 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 81 | 29 | 29 | 9 | 6 | 4.52 | .311 | 1.34 | 9.0 | 3.1 | 8.7 | 141.1 | 141 | 72 | 71 | 23 | 49 | 136 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 4.26 |
| SP | Kelly, M.Kelly, Merrill # >> | 36 | 2025 | R | 74 | 29 | 28 | 5 | 10 | 5.76 | .333 | 1.46 | 10.0 | 3.2 | 7.0 | 140.2 | 156 | 94 | 90 | 24 | 49 | 109 | 0 | 0 | 0 | 0 | 3 | 6 | 4 | 4.85 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 66 | 29 | 27 | 2 | 7 | 4.81 | .332 | 1.45 | 9.9 | 3.3 | 10.2 | 121.2 | 133 | 65 | 65 | 18 | 44 | 137 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 3.86 |
| CL | Rodríguez, R.Rodríguez, Randy † >> | 25 | 2025 | R | 94 | 69 | 0 | 4 | 6 | 3.99 | .283 | 1.16 | 8.2 | 2.2 | 12.5 | 70.0 | 64 | 31 | 31 | 10 | 17 | 97 | 0 | 29 | 6 | 0 | 0 | 2 | 3 | 2.90 |
| SU | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 91 | 76 | 0 | 4 | 3 | 2.77 | .282 | 1.17 | 7.7 | 2.8 | 9.5 | 78.0 | 67 | 28 | 24 | 8 | 24 | 82 | 0 | 7 | 3 | 0 | 0 | 1 | 1 | 3.19 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 86 | 78 | 0 | 7 | 3 | 4.78 | .332 | 1.47 | 8.8 | 4.4 | 9.7 | 96.0 | 94 | 53 | 51 | 19 | 47 | 103 | 0 | 3 | 5 | 0 | 0 | 2 | 0 | 4.96 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 82 | 80 | 0 | 8 | 4 | 4.33 | .295 | 1.24 | 7.8 | 3.5 | 10.7 | 95.2 | 82 | 47 | 46 | 12 | 37 | 113 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.46 |
| RP | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 78 | 79 | 0 | 8 | 5 | 3.56 | .301 | 1.27 | 9.0 | 2.4 | 10.7 | 86.0 | 86 | 35 | 34 | 8 | 23 | 102 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 2.71 |
| RP | Banks, T.Banks, Tanner >> | 33 | 2025 | L | 68 | 91 | 0 | 5 | 1 | 3.39 | .266 | 1.07 | 8.2 | 1.5 | 7.7 | 90.1 | 82 | 37 | 34 | 14 | 15 | 77 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.84 |