| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 20 | 20 | 7 | 7 | 3.65 | .282 | 1.17 | 8.9 | 1.6 | 6.3 | 138.0 | 137 | 57 | 56 | 11 | 24 | 97 | 4 | 0 | 0 | 1 | 13 | 2 | 1 | 3.20 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 20 | 20 | 5 | 9 | 6.09 | .346 | 1.57 | 9.7 | 4.5 | 5.6 | 115.1 | 124 | 84 | 78 | 16 | 57 | 72 | 0 | 0 | 0 | 0 | 7 | 2 | 5 | 5.10 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 21 | 20 | 8 | 6 | 5.28 | .341 | 1.54 | 9.7 | 4.1 | 6.5 | 121.0 | 131 | 73 | 71 | 9 | 55 | 87 | 2 | 0 | 0 | 0 | 9 | 2 | 5 | 3.94 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 45 | 0 | 1 | 5 | 4.08 | .280 | 1.15 | 7.9 | 2.5 | 7.3 | 57.1 | 50 | 28 | 26 | 3 | 16 | 46 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 2.96 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 37 | 0 | 4 | 0 | 3.77 | .306 | 1.30 | 8.4 | 3.4 | 8.4 | 45.1 | 42 | 21 | 19 | 8 | 17 | 42 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.64 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 31 | 0 | 3 | 4 | 5.55 | .331 | 1.49 | 9.0 | 4.6 | 9.8 | 35.2 | 35 | 22 | 22 | 1 | 18 | 38 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.74 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 18 | 0 | 2 | 0 | 4.35 | .340 | 1.50 | 10.4 | 3.6 | 10.8 | 20.2 | 23 | 10 | 10 | 0 | 8 | 24 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1.95 |
| SU | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 32 | 0 | 1 | 1 | 3.00 | .280 | 1.17 | 6.9 | 3.6 | 9.0 | 30.0 | 23 | 14 | 10 | 5 | 12 | 30 | 0 | 1 | 4 | 0 | 0 | 0 | 4 | 4.37 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 18 | 0 | 0 | 1 | 4.57 | .323 | 1.34 | 10.7 | 1.7 | 7.7 | 21.2 | 25 | 11 | 11 | 0 | 4 | 18 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.14 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 42 | 0 | 2 | 3 | 1.02 | .217 | 0.81 | 4.9 | 2.4 | 8.0 | 53.0 | 29 | 8 | 6 | 2 | 14 | 47 | 0 | 25 | 1 | 0 | 0 | 1 | 0 | 2.57 |