| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 5 | 12 | 4.48 | .308 | 1.32 | 8.2 | 3.8 | 8.6 | 182.2 | 165 | 96 | 91 | 22 | 76 | 174 | 2 | 0 | 0 | 1 | 14 | 3 | 2 | 3.96 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 27 | 27 | 8 | 13 | 5.28 | .331 | 1.46 | 10.0 | 3.2 | 4.5 | 185.2 | 206 | 112 | 109 | 26 | 66 | 93 | 9 | 0 | 0 | 1 | 10 | 3 | 4 | 4.94 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 27 | 27 | 9 | 15 | 4.88 | .322 | 1.37 | 9.2 | 3.2 | 4.6 | 182.2 | 187 | 108 | 99 | 21 | 64 | 94 | 10 | 0 | 0 | 1 | 12 | 9 | 2 | 4.67 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 24 | 24 | 3 | 10 | 6.04 | .352 | 1.61 | 10.4 | 4.2 | 7.7 | 104.1 | 120 | 80 | 70 | 9 | 48 | 89 | 0 | 0 | 0 | 0 | 2 | 2 | 6 | 3.86 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 75 | 0 | 5 | 5 | 3.77 | .273 | 1.10 | 6.5 | 3.5 | 9.1 | 86.0 | 62 | 39 | 36 | 8 | 33 | 87 | 0 | 1 | 5 | 0 | 0 | 2 | 4 | 3.41 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 65 | 0 | 2 | 5 | 4.48 | .317 | 1.33 | 8.8 | 3.2 | 9.1 | 86.1 | 84 | 43 | 43 | 8 | 31 | 87 | 0 | 6 | 2 | 0 | 0 | 5 | 2 | 3.44 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 52 | 61 | 0 | 3 | 4 | 3.51 | .288 | 1.20 | 7.8 | 3.1 | 7.5 | 66.2 | 57 | 28 | 26 | 4 | 23 | 55 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 3.21 |
| RP | Williamson, S.Williamson, Scott >> | 23 | 1999 | R | 46 | 48 | 0 | 2 | 2 | 3.66 | .310 | 1.35 | 8.0 | 4.3 | 10.0 | 46.2 | 41 | 19 | 19 | 7 | 22 | 51 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 4.20 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 3 | 2 | 1 | 0 | 4.50 | .311 | 1.36 | 10.3 | 1.9 | 3.2 | 14.0 | 16 | 7 | 7 | 3 | 3 | 5 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 5.71 |
| SP | Cuellar, M.Cuellar, Mike >> | 32 | 1969 | L | 44 | 31 | 0 | 2 | 5 | 3.72 | .310 | 1.32 | 9.0 | 3.0 | 3.8 | 48.1 | 48 | 23 | 20 | 9 | 16 | 20 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 5.67 |