| SP | McNally, D.McNally, Dave † # >> | 26 | 1968 | L | 96 | 28 | 28 | 13 | 12 | 3.80 | .291 | 1.22 | 8.7 | 2.3 | 4.8 | 208.1 | 201 | 95 | 88 | 16 | 53 | 112 | 6 | 0 | 0 | 3 | 15 | 2 | 4 | 3.72 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 28 | 28 | 10 | 14 | 6.39 | .348 | 1.57 | 10.7 | 3.5 | 3.6 | 179.0 | 212 | 128 | 127 | 31 | 69 | 71 | 1 | 0 | 0 | 0 | 11 | 6 | 6 | 5.72 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 67 | 27 | 27 | 12 | 12 | 5.22 | .332 | 1.46 | 10.2 | 3.0 | 7.6 | 189.2 | 215 | 116 | 110 | 31 | 62 | 159 | 5 | 0 | 0 | 1 | 12 | 6 | 5 | 4.53 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 25 | 25 | 11 | 5 | 4.87 | .319 | 1.40 | 8.3 | 4.3 | 4.1 | 146.0 | 134 | 82 | 79 | 16 | 70 | 66 | 0 | 0 | 0 | 0 | 15 | 1 | 3 | 4.98 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 72 | 0 | 1 | 2 | 2.38 | .277 | 1.13 | 7.4 | 2.9 | 8.9 | 94.2 | 77 | 28 | 25 | 7 | 30 | 93 | 0 | 11 | 3 | 0 | 0 | 2 | 1 | 3.01 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 60 | 0 | 3 | 1 | 2.34 | .243 | 0.92 | 5.6 | 2.7 | 6.5 | 77.0 | 48 | 20 | 20 | 6 | 23 | 56 | 0 | 11 | 3 | 0 | 0 | 3 | 0 | 3.57 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 46 | 0 | 3 | 5 | 4.45 | .336 | 1.52 | 9.5 | 4.3 | 8.7 | 54.2 | 57 | 30 | 27 | 2 | 26 | 52 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 3.00 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 2 | 1 | 0 | 0 | 7.88 | .314 | 1.38 | 9.0 | 3.4 | 6.8 | 8.0 | 8 | 7 | 7 | 3 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.50 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 21 | 0 | 2 | 2 | 6.00 | .393 | 1.88 | 8.2 | 8.7 | 10.1 | 33.0 | 30 | 22 | 22 | 3 | 32 | 37 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 5.03 |