| SP | deGrom, J.deGrom, Jacob † $$ >> | 33 | 2021 | R | 100 | 36 | 36 | 16 | 7 | 2.65 | .245 | 0.95 | 6.1 | 2.4 | 9.1 | 261.2 | 178 | 79 | 77 | 32 | 71 | 263 | 2 | 0 | 0 | 1 | 27 | 6 | 0 | 3.46 |
| SP | Arrieta, J.Arrieta, Jake † $ >> | 29 | 2015 | R | 92 | 35 | 35 | 19 | 7 | 4.40 | .289 | 1.20 | 8.3 | 2.6 | 7.4 | 251.2 | 231 | 124 | 123 | 27 | 72 | 206 | 5 | 0 | 0 | 0 | 16 | 4 | 2 | 3.67 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 33 | 33 | 12 | 12 | 3.93 | .277 | 1.13 | 7.4 | 2.8 | 9.6 | 227.0 | 186 | 105 | 99 | 32 | 70 | 243 | 1 | 0 | 0 | 0 | 20 | 5 | 5 | 3.68 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 33 | 33 | 15 | 15 | 3.92 | .290 | 1.20 | 9.0 | 1.9 | 4.8 | 257.1 | 257 | 118 | 112 | 36 | 53 | 138 | 17 | 0 | 0 | 1 | 18 | 5 | 2 | 4.42 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 31 | 31 | 10 | 9 | 4.19 | .297 | 1.25 | 8.6 | 2.7 | 7.5 | 197.2 | 189 | 96 | 92 | 36 | 59 | 164 | 0 | 0 | 0 | 0 | 15 | 3 | 11 | 4.65 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 94 | 0 | 15 | 2 | 1.44 | .242 | 0.94 | 4.9 | 3.5 | 7.8 | 125.0 | 68 | 32 | 20 | 11 | 49 | 109 | 0 | 17 | 1 | 0 | 0 | 3 | 1 | 3.65 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 92 | 77 | 0 | 8 | 1 | 2.93 | .248 | 0.99 | 7.0 | 1.9 | 8.8 | 92.0 | 72 | 31 | 30 | 7 | 19 | 90 | 0 | 12 | 7 | 0 | 0 | 0 | 1 | 2.65 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 51 | 0 | 4 | 7 | 2.80 | .265 | 1.06 | 7.5 | 2.2 | 7.2 | 54.2 | 45 | 25 | 17 | 10 | 13 | 43 | 0 | 9 | 1 | 0 | 0 | 1 | 0 | 4.59 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 30 | 0 | 2 | 3 | 2.97 | .265 | 1.08 | 7.1 | 2.7 | 6.3 | 33.1 | 26 | 12 | 11 | 3 | 10 | 23 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.70 |