| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 28 | 28 | 16 | 6 | 3.77 | .267 | 1.08 | 7.8 | 1.9 | 9.6 | 179.0 | 155 | 77 | 75 | 24 | 38 | 191 | 3 | 0 | 0 | 0 | 19 | 3 | 0 | 3.30 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 28 | 28 | 11 | 8 | 4.32 | .319 | 1.37 | 9.6 | 2.8 | 8.5 | 175.0 | 186 | 93 | 84 | 23 | 54 | 166 | 2 | 0 | 0 | 2 | 15 | 6 | 2 | 3.84 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 27 | 27 | 14 | 7 | 3.86 | .292 | 1.21 | 8.7 | 2.3 | 4.0 | 196.0 | 189 | 95 | 84 | 15 | 49 | 88 | 5 | 0 | 0 | 0 | 15 | 4 | 6 | 3.91 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 27 | 27 | 9 | 12 | 5.17 | .299 | 1.27 | 9.3 | 2.2 | 6.9 | 175.2 | 181 | 101 | 101 | 27 | 42 | 134 | 5 | 0 | 0 | 0 | 11 | 2 | 3 | 4.23 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 71 | 0 | 5 | 5 | 3.15 | .249 | 0.99 | 6.5 | 2.4 | 9.1 | 91.1 | 66 | 32 | 32 | 10 | 24 | 92 | 0 | 7 | 4 | 0 | 0 | 1 | 0 | 3.23 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 55 | 0 | 6 | 3 | 3.48 | .289 | 1.22 | 7.2 | 3.9 | 9.0 | 64.2 | 51 | 26 | 25 | 5 | 28 | 64 | 0 | 4 | 2 | 0 | 0 | 0 | 4 | 3.33 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 35 | 0 | 4 | 1 | 1.74 | .200 | 0.75 | 5.3 | 1.5 | 7.0 | 41.1 | 24 | 8 | 8 | 4 | 7 | 32 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 3.22 |