| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 8 | 8 | 4 | 2 | 4.39 | .288 | 1.17 | 8.2 | 2.5 | 7.4 | 55.1 | 50 | 28 | 27 | 5 | 15 | 45 | 2 | 0 | 0 | 2 | 3 | 2 | 1 | 3.47 |
| SP | Kluber, C.Kluber, Corey $ >> | 31 | 2017 | R | 89 | 8 | 8 | 3 | 3 | 4.37 | .313 | 1.35 | 10.1 | 2.1 | 9.3 | 55.2 | 62 | 28 | 27 | 4 | 13 | 57 | 0 | 0 | 0 | 0 | 3 | 1 | 5 | 2.64 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 8 | 8 | 2 | 5 | 5.60 | .315 | 1.34 | 9.0 | 3.1 | 7.1 | 53.0 | 53 | 34 | 33 | 6 | 18 | 42 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 4.02 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 8 | 8 | 4 | 3 | 4.95 | .316 | 1.35 | 8.7 | 3.5 | 3.4 | 56.1 | 54 | 31 | 31 | 10 | 22 | 21 | 3 | 0 | 0 | 0 | 3 | 2 | 0 | 5.86 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 9 | 8 | 3 | 3 | 4.55 | .331 | 1.45 | 9.8 | 3.3 | 6.5 | 55.1 | 60 | 28 | 28 | 4 | 20 | 40 | 1 | 0 | 0 | 0 | 4 | 2 | 2 | 3.69 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 25 | 0 | 0 | 2 | 2.76 | .323 | 1.36 | 6.8 | 5.6 | 11.8 | 29.1 | 22 | 9 | 9 | 2 | 18 | 38 | 0 | 5 | 0 | 0 | 0 | 2 | 2 | 3.34 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 16 | 0 | 2 | 1 | 1.59 | .301 | 1.29 | 6.4 | 5.3 | 9.0 | 17.0 | 12 | 3 | 3 | 1 | 10 | 17 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.53 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 6 | 0 | 0 | 1 | 1.23 | .214 | 0.68 | 3.9 | 2.6 | 11.6 | 7.1 | 3 | 1 | 1 | 0 | 2 | 9 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1.71 |
| RP | Bautista, F.Bautista, Félix $ >> | 28 | 2023 | R | 74 | 7 | 0 | 1 | 0 | 2.70 | .259 | 0.90 | 3.0 | 6.0 | 10.5 | 6.2 | 2 | 2 | 2 | 0 | 4 | 7 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.17 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 3 | 0 | 1 | 0 | 7.36 | .389 | 1.91 | 21.0 | 0.0 | 18.0 | 3.2 | 7 | 3 | 3 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1.00 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 5 | 0 | 0 | 0 | 1.69 | .360 | 1.69 | 7.2 | 9.0 | 14.4 | 5.1 | 4 | 1 | 1 | 0 | 5 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.80 |