| SP | McNally, D.McNally, Dave $ >> | 26 | 1968 | L | 96 | 13 | 13 | 4 | 4 | 3.77 | .286 | 1.18 | 8.2 | 2.4 | 5.9 | 93.0 | 85 | 40 | 39 | 13 | 25 | 61 | 2 | 0 | 0 | 1 | 7 | 2 | 2 | 4.38 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 12 | 12 | 4 | 5 | 4.75 | .298 | 1.25 | 7.7 | 3.6 | 8.3 | 77.2 | 66 | 41 | 41 | 13 | 31 | 71 | 2 | 0 | 0 | 1 | 5 | 2 | 0 | 4.64 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 12 | 12 | 5 | 4 | 4.70 | .283 | 1.16 | 8.1 | 2.4 | 8.0 | 84.1 | 76 | 46 | 44 | 16 | 22 | 75 | 1 | 0 | 0 | 0 | 6 | 2 | 1 | 4.55 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 12 | 12 | 4 | 5 | 6.05 | .332 | 1.48 | 10.5 | 2.9 | 5.1 | 80.1 | 93 | 59 | 54 | 8 | 26 | 45 | 4 | 0 | 0 | 0 | 4 | 1 | 1 | 4.19 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 31 | 0 | 2 | 3 | 3.76 | .315 | 1.36 | 9.2 | 3.1 | 8.8 | 38.1 | 39 | 18 | 16 | 6 | 13 | 37 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 4.21 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 26 | 0 | 2 | 1 | 3.30 | .268 | 1.07 | 6.3 | 3.3 | 10.5 | 30.0 | 21 | 11 | 11 | 4 | 11 | 35 | 0 | 6 | 0 | 0 | 0 | 1 | 1 | 3.60 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 16 | 0 | 0 | 1 | 2.41 | .263 | 1.02 | 6.0 | 3.5 | 9.0 | 18.2 | 12 | 5 | 5 | 0 | 7 | 18 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 2.33 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 11 | 0 | 2 | 1 | 0.71 | .224 | 0.87 | 5.3 | 3.0 | 6.8 | 12.2 | 7 | 2 | 1 | 0 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.50 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 12 | 0 | 0 | 0 | 6.35 | .370 | 1.76 | 9.8 | 6.5 | 9.8 | 11.1 | 12 | 8 | 8 | 4 | 8 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 7.73 |