| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 66 | 33 | 33 | 8 | 10 | 4.62 | .315 | 1.37 | 10.0 | 2.4 | 6.7 | 206.1 | 228 | 108 | 106 | 30 | 54 | 154 | 1 | 0 | 0 | 1 | 15 | 2 | 3 | 4.21 |
| SP | Santana, E.Santana, Ervin # >> | 25 | 2008 | R | 54 | 32 | 32 | 8 | 19 | 5.67 | .324 | 1.43 | 10.1 | 2.8 | 7.8 | 185.2 | 207 | 124 | 117 | 38 | 58 | 160 | 0 | 0 | 0 | 0 | 11 | 2 | 6 | 4.91 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 38 | 32 | 32 | 7 | 9 | 5.38 | .348 | 1.58 | 9.4 | 4.9 | 6.5 | 185.2 | 193 | 116 | 111 | 31 | 100 | 133 | 0 | 0 | 0 | 0 | 12 | 4 | 5 | 5.43 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 98 | 0 | 9 | 1 | 2.48 | .257 | 0.99 | 5.2 | 3.7 | 10.7 | 109.0 | 63 | 31 | 30 | 9 | 45 | 130 | 0 | 6 | 3 | 0 | 0 | 5 | 0 | 3.06 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 55 | 86 | 0 | 5 | 8 | 5.09 | .315 | 1.31 | 8.5 | 3.4 | 5.2 | 88.1 | 83 | 51 | 50 | 25 | 33 | 51 | 0 | 12 | 7 | 0 | 0 | 6 | 3 | 6.86 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 38 | 66 | 0 | 7 | 6 | 4.33 | .296 | 1.25 | 8.4 | 3.0 | 6.9 | 70.2 | 65 | 34 | 34 | 12 | 23 | 54 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 4.71 |
| RP | Corpas, M.Corpas, Manuel >> | 25 | 2007 | R | 23 | 55 | 0 | 7 | 1 | 2.70 | .273 | 1.11 | 7.2 | 2.9 | 6.3 | 66.2 | 53 | 26 | 20 | 7 | 21 | 46 | 0 | 8 | 2 | 0 | 0 | 1 | 0 | 3.98 |
| RP | Romero, J.Romero, J.C. >> | 26 | 2002 | L | 12 | 114 | 0 | 0 | 2 | 5.35 | .338 | 1.47 | 8.5 | 4.8 | 8.2 | 67.1 | 63 | 43 | 40 | 6 | 36 | 61 | 0 | 4 | 2 | 0 | 0 | 4 | 5 | 4.13 |
| SP | Rodriguez, W.Rodriguez, Wandy >> | 30 | 2009 | L | 12 | 31 | 0 | 3 | 5 | 4.42 | .359 | 1.68 | 11.4 | 4.0 | 9.0 | 38.2 | 48 | 22 | 19 | 6 | 17 | 38 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 4.39 |