| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 29 | 29 | 5 | 11 | 5.57 | .326 | 1.43 | 9.4 | 3.5 | 8.9 | 126.0 | 131 | 78 | 78 | 20 | 49 | 125 | 0 | 0 | 0 | 0 | 2 | 3 | 6 | 4.32 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 27 | 27 | 10 | 8 | 4.69 | .271 | 1.08 | 8.5 | 1.3 | 6.8 | 169.0 | 159 | 88 | 88 | 30 | 24 | 128 | 1 | 0 | 0 | 1 | 17 | 5 | 3 | 4.31 |
| SP | Hamels, C.Hamels, Cole † >> | 25 | 2008 | L | 72 | 28 | 26 | 15 | 6 | 5.71 | .326 | 1.42 | 9.7 | 3.1 | 7.0 | 145.0 | 156 | 94 | 92 | 30 | 50 | 112 | 0 | 0 | 0 | 0 | 11 | 4 | 0 | 5.26 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 70 | 0 | 4 | 3 | 4.52 | .305 | 1.27 | 7.0 | 4.6 | 10.6 | 63.2 | 49 | 32 | 32 | 7 | 32 | 74 | 0 | 12 | 2 | 0 | 0 | 3 | 7 | 3.76 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 44 | 0 | 2 | 1 | 2.23 | .300 | 1.22 | 6.8 | 4.3 | 7.4 | 44.1 | 33 | 11 | 11 | 4 | 21 | 36 | 0 | 8 | 1 | 0 | 0 | 3 | 2 | 4.18 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 27 | 0 | 2 | 4 | 4.15 | .284 | 1.15 | 7.3 | 3.1 | 8.7 | 26.0 | 21 | 14 | 12 | 4 | 9 | 25 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 4.23 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 73 | 0 | 5 | 5 | 2.14 | .253 | 0.97 | 5.6 | 3.1 | 5.9 | 59.0 | 37 | 14 | 14 | 4 | 20 | 39 | 0 | 7 | 2 | 0 | 0 | 3 | 0 | 3.73 |