| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 100 | 29 | 29 | 14 | 9 | 3.19 | .285 | 1.19 | 8.3 | 2.4 | 8.5 | 192.0 | 178 | 74 | 68 | 18 | 51 | 182 | 2 | 0 | 0 | 0 | 19 | 1 | 2 | 3.14 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 28 | 28 | 11 | 7 | 4.60 | .298 | 1.26 | 8.6 | 2.8 | 8.5 | 170.1 | 162 | 96 | 87 | 34 | 52 | 161 | 1 | 0 | 0 | 1 | 14 | 3 | 2 | 4.68 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 77 | 27 | 27 | 11 | 11 | 4.72 | .325 | 1.42 | 9.9 | 3.0 | 8.4 | 167.2 | 183 | 97 | 88 | 28 | 55 | 156 | 0 | 0 | 0 | 0 | 12 | 4 | 6 | 4.37 |
| CL | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 58 | 0 | 2 | 6 | 3.90 | .313 | 1.35 | 8.7 | 3.5 | 9.0 | 60.0 | 58 | 27 | 26 | 10 | 23 | 60 | 0 | 26 | 4 | 0 | 0 | 1 | 0 | 4.37 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 76 | 0 | 5 | 1 | 3.55 | .283 | 1.18 | 6.7 | 4.0 | 10.2 | 58.1 | 43 | 27 | 23 | 8 | 26 | 66 | 0 | 2 | 3 | 0 | 0 | 0 | 2 | 3.86 |
| RP | Foulke, K.Foulke, Keith † >> | 31 | 2003 | R | 78 | 79 | 0 | 6 | 2 | 2.98 | .269 | 1.10 | 7.9 | 2.1 | 9.4 | 90.2 | 79 | 30 | 30 | 12 | 21 | 94 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 3.34 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 59 | 0 | 6 | 0 | 1.21 | .226 | 0.83 | 4.5 | 3.0 | 10.6 | 74.1 | 37 | 12 | 10 | 3 | 25 | 87 | 0 | 1 | 1 | 0 | 0 | 3 | 7 | 2.31 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 54 | 0 | 3 | 2 | 3.27 | .294 | 1.23 | 7.3 | 3.9 | 9.9 | 63.1 | 51 | 25 | 23 | 10 | 27 | 69 | 0 | 0 | 2 | 0 | 0 | 1 | 5 | 4.21 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 18 | 0 | 3 | 1 | 3.09 | .276 | 1.11 | 8.0 | 2.1 | 5.7 | 35.0 | 31 | 12 | 12 | 2 | 8 | 22 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 3.26 |