| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 100 | 34 | 34 | 18 | 9 | 3.42 | .286 | 1.18 | 8.1 | 2.5 | 10.1 | 236.2 | 213 | 91 | 90 | 29 | 66 | 265 | 1 | 0 | 0 | 1 | 21 | 6 | 7 | 3.27 |
| SP | Peavy, J.Peavy, Jake † >> | 26 | 2007 | R | 88 | 33 | 33 | 17 | 8 | 4.36 | .320 | 1.38 | 8.8 | 3.7 | 8.4 | 218.2 | 212 | 110 | 106 | 30 | 90 | 204 | 0 | 0 | 0 | 0 | 17 | 6 | 1 | 4.24 |
| SP | Sabathia, C.Sabathia, CC # >> | 28 | 2008 | L | 61 | 32 | 32 | 16 | 9 | 4.92 | .330 | 1.42 | 9.3 | 3.5 | 8.0 | 225.0 | 232 | 128 | 123 | 32 | 87 | 200 | 2 | 0 | 0 | 0 | 15 | 14 | 1 | 4.42 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 43 | 31 | 31 | 11 | 9 | 5.42 | .358 | 1.65 | 10.7 | 4.2 | 8.9 | 197.2 | 235 | 127 | 119 | 27 | 92 | 194 | 0 | 0 | 0 | 0 | 14 | 3 | 7 | 4.26 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 95 | 71 | 0 | 11 | 5 | 2.93 | .248 | 0.94 | 6.8 | 1.7 | 9.0 | 73.2 | 55 | 25 | 24 | 7 | 14 | 73 | 0 | 40 | 5 | 0 | 0 | 4 | 1 | 2.99 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 61 | 0 | 2 | 1 | 3.45 | .309 | 1.29 | 7.3 | 4.4 | 9.5 | 57.1 | 46 | 23 | 22 | 4 | 28 | 60 | 0 | 6 | 2 | 0 | 0 | 3 | 0 | 3.44 |
| RP | Okajima, H.Okajima, Hideki # >> | 32 | 2007 | L | 51 | 59 | 0 | 7 | 3 | 4.25 | .292 | 1.19 | 8.1 | 2.6 | 6.3 | 72.0 | 65 | 35 | 34 | 8 | 21 | 50 | 0 | 2 | 6 | 0 | 0 | 3 | 0 | 4.06 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 61 | 0 | 7 | 3 | 2.48 | .301 | 1.28 | 7.8 | 3.9 | 10.4 | 72.2 | 62 | 20 | 20 | 3 | 31 | 83 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 2.57 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 75 | 38 | 0 | 3 | 1 | 4.78 | .302 | 1.30 | 7.8 | 4.1 | 10.0 | 37.2 | 32 | 22 | 20 | 6 | 17 | 41 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 4.27 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 50 | 0 | 1 | 3 | 4.83 | .339 | 1.50 | 8.5 | 5.0 | 11.2 | 54.0 | 51 | 29 | 29 | 12 | 30 | 67 | 0 | 0 | 2 | 0 | 0 | 2 | 2 | 5.19 |
| SP | Wainwright, A.Wainwright, Adam >> | 28 | 2009 | R | 18 | 3 | 0 | 0 | 0 | 3.38 | .375 | 1.80 | 13.8 | 2.8 | 9.7 | 13.1 | 20 | 5 | 5 | 2 | 4 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.77 |