| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 32 | 32 | 12 | 15 | 4.08 | .302 | 1.26 | 7.7 | 3.7 | 10.0 | 214.0 | 183 | 99 | 97 | 30 | 87 | 237 | 4 | 0 | 0 | 0 | 20 | 8 | 7 | 3.94 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 32 | 32 | 7 | 15 | 5.18 | .321 | 1.41 | 10.0 | 2.7 | 9.0 | 184.1 | 204 | 113 | 106 | 36 | 55 | 183 | 0 | 0 | 0 | 0 | 16 | 3 | 6 | 4.50 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 32 | 32 | 7 | 14 | 5.80 | .338 | 1.50 | 10.3 | 3.2 | 6.0 | 181.2 | 208 | 122 | 117 | 29 | 64 | 120 | 0 | 0 | 0 | 0 | 12 | 6 | 4 | 4.92 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 32 | 32 | 8 | 10 | 5.71 | .337 | 1.49 | 11.0 | 2.4 | 6.7 | 181.1 | 222 | 124 | 115 | 36 | 49 | 134 | 0 | 0 | 0 | 0 | 13 | 5 | 4 | 5.00 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 30 | 30 | 10 | 12 | 5.13 | .303 | 1.28 | 9.4 | 2.2 | 7.0 | 177.1 | 184 | 108 | 101 | 39 | 43 | 138 | 2 | 0 | 0 | 0 | 15 | 4 | 4 | 5.10 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 96 | 0 | 8 | 2 | 4.57 | .292 | 1.21 | 7.6 | 3.3 | 9.5 | 104.1 | 88 | 55 | 53 | 14 | 38 | 110 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 3.82 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 89 | 0 | 2 | 2 | 3.75 | .301 | 1.27 | 7.3 | 4.2 | 9.8 | 98.1 | 79 | 41 | 41 | 15 | 46 | 107 | 0 | 4 | 5 | 0 | 0 | 2 | 0 | 4.28 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 72 | 0 | 7 | 8 | 3.53 | .253 | 0.98 | 6.0 | 2.9 | 12.3 | 81.2 | 54 | 32 | 32 | 12 | 26 | 111 | 0 | 31 | 3 | 0 | 0 | 3 | 0 | 3.26 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 78 | 4 | 3 | 2 | 1 | 3.66 | .366 | 1.68 | 9.0 | 6.6 | 5.7 | 19.2 | 19 | 11 | 8 | 2 | 14 | 12 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 5.47 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 47 | 2 | 1 | 0 | 1 | 10.61 | .378 | 1.82 | 13.0 | 4.0 | 9.0 | 9.1 | 13 | 11 | 11 | 3 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.67 |