| SP | Schilling, C.Schilling, Curt # $ >> | 36 | 2002 | R | 93 | 18 | 18 | 7 | 5 | 4.92 | .293 | 1.21 | 9.0 | 1.9 | 10.0 | 119.0 | 119 | 66 | 65 | 19 | 25 | 132 | 2 | 0 | 0 | 0 | 10 | 4 | 1 | 3.59 |
| SP | Wakefield, T.Wakefield, Tim $$ >> | 36 | 2002 | R | 85 | 17 | 17 | 3 | 2 | 1.75 | .259 | 1.01 | 6.7 | 2.5 | 6.3 | 77.1 | 57 | 15 | 15 | 2 | 21 | 54 | 0 | 0 | 0 | 0 | 1 | 3 | 4 | 2.87 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 17 | 17 | 7 | 6 | 5.31 | .328 | 1.38 | 9.9 | 2.6 | 7.9 | 103.1 | 113 | 64 | 61 | 19 | 30 | 90 | 0 | 0 | 0 | 0 | 6 | 8 | 2 | 4.76 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 16 | 16 | 3 | 8 | 5.32 | .343 | 1.55 | 12.0 | 2.1 | 6.6 | 91.1 | 121 | 63 | 54 | 13 | 21 | 67 | 0 | 0 | 0 | 0 | 5 | 1 | 3 | 4.11 |
| CL | Papelbon, J.Papelbon, Jonathan $$ >> | 26 | 2006 | R | 93 | 33 | 0 | 3 | 5 | 5.97 | .345 | 1.55 | 10.2 | 4.1 | 10.5 | 31.2 | 35 | 21 | 21 | 3 | 14 | 36 | 0 | 20 | 4 | 0 | 0 | 1 | 2 | 3.39 |
| SU | Marmol, C.Marmol, Carlos $$ >> | 26 | 2008 | R | 86 | 41 | 0 | 3 | 0 | 1.53 | .242 | 0.96 | 3.1 | 5.6 | 9.6 | 47.0 | 16 | 8 | 8 | 1 | 29 | 50 | 0 | 3 | 1 | 0 | 0 | 0 | 3 | 3.00 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 40 | 0 | 5 | 0 | 2.54 | .299 | 1.26 | 6.1 | 5.3 | 9.8 | 46.0 | 31 | 13 | 13 | 3 | 27 | 50 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.50 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 50 | 0 | 6 | 1 | 4.34 | .356 | 1.63 | 10.7 | 4.1 | 10.2 | 37.1 | 44 | 19 | 18 | 0 | 17 | 42 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.19 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 42 | 0 | 1 | 3 | 4.56 | .327 | 1.40 | 9.6 | 3.1 | 7.5 | 49.1 | 52 | 27 | 25 | 10 | 17 | 41 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.20 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 59 | 28 | 0 | 2 | 0 | 3.94 | .310 | 1.28 | 7.8 | 4.0 | 8.4 | 29.2 | 25 | 13 | 13 | 3 | 13 | 27 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.03 |