| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 18 | 18 | 3 | 8 | 5.62 | .354 | 1.57 | 11.0 | 3.3 | 9.9 | 73.2 | 89 | 48 | 46 | 14 | 27 | 80 | 0 | 0 | 0 | 0 | 2 | 5 | 3 | 4.62 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 18 | 18 | 5 | 4 | 3.25 | .290 | 1.22 | 8.4 | 2.6 | 6.3 | 119.0 | 111 | 50 | 43 | 18 | 34 | 83 | 0 | 0 | 0 | 0 | 11 | 1 | 1 | 4.45 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 17 | 17 | 5 | 5 | 5.57 | .368 | 1.69 | 9.3 | 5.9 | 6.3 | 108.1 | 112 | 71 | 67 | 22 | 71 | 76 | 1 | 0 | 0 | 0 | 6 | 6 | 5 | 6.38 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 52 | 17 | 17 | 4 | 7 | 5.84 | .344 | 1.55 | 10.5 | 3.6 | 6.2 | 101.2 | 118 | 66 | 66 | 18 | 40 | 70 | 0 | 0 | 0 | 0 | 8 | 2 | 2 | 5.18 |
| SP | Willis, D.Willis, Dontrelle # >> | 23 | 2005 | L | 49 | 15 | 15 | 7 | 5 | 5.27 | .301 | 1.26 | 9.3 | 2.1 | 5.3 | 97.1 | 100 | 60 | 57 | 16 | 23 | 57 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 4.77 |
| RP | Soriano, R.Soriano, Rafael † >> | 24 | 2003 | R | 97 | 48 | 0 | 8 | 1 | 3.38 | .264 | 1.05 | 7.1 | 2.4 | 8.6 | 80.0 | 63 | 31 | 30 | 12 | 21 | 76 | 0 | 3 | 4 | 0 | 0 | 2 | 0 | 3.91 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 39 | 0 | 5 | 2 | 4.70 | .323 | 1.37 | 8.1 | 4.4 | 10.4 | 51.2 | 46 | 30 | 27 | 10 | 25 | 59 | 0 | 2 | 4 | 0 | 0 | 3 | 3 | 4.88 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 43 | 0 | 3 | 2 | 3.67 | .326 | 1.37 | 7.0 | 5.3 | 8.8 | 49.0 | 38 | 23 | 20 | 11 | 29 | 48 | 0 | 6 | 3 | 0 | 0 | 4 | 2 | 5.98 |
| RP | Guerrier, M.Guerrier, Matt >> | 31 | 2009 | R | 42 | 32 | 0 | 0 | 6 | 8.49 | .364 | 1.69 | 11.8 | 3.3 | 4.4 | 35.0 | 46 | 36 | 33 | 10 | 13 | 17 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 6.94 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 1 | 0 | 0 | 1 | 6.75 | .667 | 6.00 | 36.0 | 36.0 | 9.0 | 1.1 | 4 | 1 | 1 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13.00 |