| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 100 | 22 | 22 | 6 | 12 | 4.81 | .312 | 1.34 | 9.3 | 2.8 | 9.0 | 149.2 | 154 | 81 | 80 | 25 | 47 | 149 | 2 | 0 | 0 | 2 | 10 | 3 | 1 | 4.19 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 22 | 22 | 8 | 6 | 5.67 | .334 | 1.46 | 11.1 | 2.1 | 6.7 | 131.2 | 161 | 87 | 83 | 28 | 31 | 98 | 0 | 0 | 0 | 0 | 9 | 6 | 3 | 5.13 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 21 | 21 | 5 | 12 | 7.49 | .374 | 1.73 | 9.8 | 5.8 | 8.5 | 119.0 | 129 | 100 | 99 | 16 | 77 | 112 | 0 | 0 | 0 | 0 | 6 | 7 | 8 | 4.98 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 21 | 21 | 6 | 11 | 6.17 | .321 | 1.38 | 10.2 | 2.3 | 7.9 | 128.1 | 145 | 89 | 88 | 29 | 32 | 113 | 1 | 0 | 0 | 1 | 7 | 5 | 3 | 5.05 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 58 | 0 | 3 | 3 | 2.26 | .297 | 1.24 | 7.1 | 4.2 | 10.5 | 79.2 | 62 | 22 | 20 | 8 | 37 | 92 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 3.47 |
| RP | Gordon, T.Gordon, Tom # >> | 37 | 2004 | R | 81 | 52 | 0 | 3 | 3 | 6.07 | .369 | 1.70 | 10.5 | 4.9 | 7.8 | 59.1 | 69 | 43 | 40 | 13 | 32 | 51 | 0 | 5 | 2 | 0 | 0 | 3 | 0 | 5.92 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 57 | 45 | 0 | 1 | 2 | 6.04 | .336 | 1.48 | 8.5 | 5.0 | 7.0 | 50.2 | 47 | 34 | 34 | 12 | 28 | 39 | 0 | 4 | 2 | 0 | 0 | 2 | 1 | 6.36 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 47 | 38 | 0 | 2 | 1 | 6.25 | .339 | 1.51 | 8.8 | 5.0 | 8.8 | 40.1 | 39 | 32 | 28 | 8 | 22 | 39 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 5.38 |
| RP | Aardsma, D.Aardsma, David >> | 28 | 2009 | R | 38 | 36 | 0 | 1 | 3 | 6.16 | .409 | 2.03 | 12.3 | 5.9 | 11.1 | 38.0 | 52 | 28 | 26 | 7 | 25 | 47 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 5.05 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 2 | 0 | 0 | 0 | 0.00 | .222 | 0.86 | 9.0 | 0.0 | 9.0 | 2.1 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 18 | 0 | 0 | 2 | 10.53 | .410 | 2.03 | 13.3 | 5.7 | 9.0 | 19.2 | 28 | 23 | 23 | 7 | 12 | 19 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 7.84 |