| SP | Skubal, T.Skubal, Tarik $$ >> | 28 | 2025 | L | 100 | 22 | 22 | 7 | 6 | 3.47 | .299 | 1.25 | 8.1 | 3.1 | 11.0 | 147.2 | 133 | 62 | 57 | 17 | 51 | 179 | 0 | 0 | 0 | 0 | 15 | 5 | 2 | 3.21 |
| SP | Rodon, C.Rodon, Carlos $$ >> | 32 | 2025 | L | 92 | 20 | 20 | 8 | 9 | 3.80 | .292 | 1.19 | 7.1 | 3.6 | 9.5 | 123.0 | 97 | 57 | 52 | 15 | 49 | 130 | 0 | 0 | 0 | 0 | 11 | 6 | 0 | 3.81 |
| SP | Pérez, E.Pérez, Eury # >> | 22 | 2025 | R | 90 | 21 | 21 | 7 | 7 | 3.66 | .298 | 1.24 | 8.4 | 2.8 | 9.6 | 110.2 | 103 | 46 | 45 | 13 | 34 | 117 | 1 | 0 | 0 | 1 | 6 | 4 | 3 | 3.45 |
| SP | Imanaga, S.Imanaga, Shota † >> | 31 | 2025 | L | 83 | 20 | 20 | 11 | 4 | 3.88 | .302 | 1.27 | 8.6 | 2.9 | 7.5 | 123.0 | 117 | 58 | 53 | 15 | 39 | 103 | 0 | 0 | 0 | 0 | 13 | 4 | 1 | 3.96 |
| CL | Speier, G.Speier, Gabe >> | 30 | 2025 | L | 96 | 37 | 0 | 1 | 9 | 3.93 | .281 | 1.09 | 7.8 | 2.3 | 12.3 | 36.2 | 31 | 17 | 16 | 6 | 9 | 49 | 0 | 19 | 3 | 0 | 0 | 3 | 0 | 3.44 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 91 | 58 | 0 | 2 | 4 | 2.61 | .273 | 1.13 | 7.6 | 2.6 | 10.1 | 58.2 | 49 | 17 | 17 | 8 | 17 | 65 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 3.43 |
| RP | Bautista, F.Bautista, Félix >> | 30 | 2025 | R | 84 | 39 | 0 | 1 | 1 | 4.78 | .319 | 1.37 | 4.2 | 8.3 | 11.8 | 26.1 | 12 | 15 | 14 | 3 | 24 | 34 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.77 |
| SP | Springs, J.Springs, Jeffrey >> | 32 | 2025 | L | 67 | 14 | 1 | 2 | 1 | 4.72 | .335 | 1.49 | 10.7 | 2.9 | 8.2 | 47.2 | 56 | 28 | 25 | 6 | 15 | 43 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.85 |