| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 92 | 27 | 27 | 11 | 8 | 3.84 | .304 | 1.29 | 9.3 | 2.3 | 9.0 | 175.2 | 181 | 82 | 75 | 20 | 45 | 175 | 0 | 0 | 0 | 0 | 19 | 4 | 5 | 3.33 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 88 | 26 | 26 | 11 | 9 | 4.10 | .297 | 1.27 | 8.2 | 3.2 | 5.9 | 195.1 | 178 | 89 | 89 | 16 | 70 | 128 | 7 | 0 | 0 | 0 | 15 | 0 | 4 | 3.83 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 76 | 25 | 25 | 11 | 7 | 4.18 | .301 | 1.27 | 8.8 | 2.8 | 7.4 | 150.2 | 146 | 78 | 70 | 16 | 46 | 124 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 3.71 |
| SP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 87 | 25 | 25 | 0 | 3 | 3.82 | .315 | 1.34 | 10.1 | 2.0 | 5.0 | 63.2 | 71 | 31 | 27 | 4 | 14 | 35 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.52 |
| SP | Timmermann, T.Timmermann, Tom >> | 32 | 1972 | R | 48 | 25 | 24 | 9 | 4 | 4.24 | .310 | 1.34 | 8.2 | 3.9 | 6.4 | 116.2 | 106 | 57 | 55 | 9 | 50 | 83 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 3.90 |
| RP | Holton, T.Holton, Tyler † >> | 28 | 2024 | L | 77 | 67 | 0 | 11 | 2 | 3.08 | .246 | 0.98 | 7.6 | 1.3 | 6.7 | 87.2 | 73 | 31 | 30 | 7 | 13 | 65 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 54 | 72 | 0 | 4 | 2 | 3.03 | .290 | 1.16 | 6.9 | 3.5 | 8.0 | 74.1 | 57 | 28 | 25 | 8 | 29 | 66 | 0 | 2 | 5 | 0 | 0 | 5 | 1 | 4.00 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 59 | 65 | 0 | 7 | 1 | 2.80 | .270 | 1.10 | 6.9 | 3.0 | 6.3 | 80.1 | 61 | 25 | 25 | 3 | 27 | 56 | 0 | 2 | 1 | 0 | 0 | 1 | 5 | 3.14 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 40 | 53 | 0 | 2 | 2 | 3.69 | .291 | 1.17 | 7.7 | 2.9 | 5.7 | 63.1 | 54 | 28 | 26 | 7 | 20 | 40 | 0 | 1 | 4 | 0 | 0 | 4 | 3 | 4.32 |
| SP | Sanchez, A.Sanchez, Anibal >> | 30 | 2014 | R | 47 | 25 | 0 | 5 | 5 | 7.31 | .401 | 1.98 | 14.8 | 3.2 | 5.1 | 28.1 | 46 | 23 | 23 | 3 | 10 | 16 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 4.43 |
| CL | Greene, S.Greene, Shane † >> | 30 | 2019 | R | 79 | 55 | 0 | 3 | 4 | 2.98 | .301 | 1.28 | 7.1 | 4.4 | 10.3 | 63.1 | 50 | 25 | 21 | 3 | 31 | 72 | 0 | 20 | 5 | 0 | 0 | 1 | 0 | 2.86 |