| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 31 | 31 | 23 | 5 | 2.75 | .270 | 1.08 | 7.0 | 2.7 | 7.7 | 239.1 | 187 | 81 | 73 | 16 | 72 | 205 | 13 | 0 | 0 | 4 | 23 | 6 | 9 | 3.13 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 29 | 29 | 12 | 11 | 4.30 | .299 | 1.26 | 9.4 | 2.0 | 5.1 | 190.1 | 198 | 95 | 91 | 21 | 42 | 107 | 8 | 0 | 0 | 1 | 14 | 4 | 2 | 4.04 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 29 | 29 | 10 | 9 | 4.84 | .300 | 1.26 | 8.7 | 2.7 | 3.9 | 191.1 | 184 | 109 | 103 | 31 | 57 | 83 | 7 | 0 | 0 | 1 | 11 | 5 | 0 | 5.21 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 28 | 28 | 10 | 13 | 5.39 | .324 | 1.41 | 9.6 | 3.2 | 5.3 | 173.2 | 184 | 108 | 104 | 26 | 61 | 101 | 6 | 0 | 0 | 1 | 11 | 5 | 2 | 4.93 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 68 | 0 | 7 | 3 | 2.62 | .242 | 0.95 | 6.8 | 1.8 | 8.7 | 82.1 | 62 | 25 | 24 | 9 | 16 | 79 | 0 | 10 | 2 | 0 | 0 | 1 | 0 | 3.12 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 48 | 0 | 1 | 2 | 5.14 | .366 | 1.73 | 10.3 | 5.3 | 9.7 | 49.0 | 56 | 33 | 28 | 8 | 29 | 53 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 4.73 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 27 | 0 | 4 | 2 | 4.18 | .306 | 1.32 | 5.8 | 6.1 | 8.0 | 28.0 | 18 | 14 | 13 | 1 | 19 | 25 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.71 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 76 | 11 | 0 | 0 | 0 | 6.75 | .333 | 1.50 | 8.3 | 5.3 | 11.3 | 12.0 | 11 | 9 | 9 | 1 | 7 | 15 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.33 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 22 | 0 | 0 | 0 | 3.33 | .296 | 1.26 | 8.0 | 3.3 | 7.3 | 27.0 | 24 | 10 | 10 | 3 | 10 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.93 |