| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 31 | 31 | 6 | 16 | 4.51 | .301 | 1.27 | 8.7 | 2.8 | 9.6 | 187.2 | 181 | 100 | 94 | 35 | 58 | 199 | 0 | 0 | 0 | 0 | 14 | 3 | 0 | 4.28 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 30 | 30 | 14 | 11 | 5.35 | .345 | 1.56 | 10.2 | 3.8 | 4.5 | 198.1 | 225 | 127 | 118 | 28 | 84 | 98 | 3 | 0 | 0 | 0 | 16 | 4 | 6 | 5.18 |
| SP | Overall, O.Overall, Orval # >> | 28 | 1909 | R | 57 | 28 | 28 | 11 | 14 | 4.01 | .310 | 1.32 | 8.4 | 3.5 | 5.3 | 197.2 | 184 | 94 | 88 | 22 | 76 | 115 | 2 | 0 | 0 | 0 | 15 | 7 | 3 | 4.55 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 80 | 0 | 7 | 2 | 3.41 | .272 | 1.10 | 6.9 | 3.1 | 10.1 | 118.2 | 90 | 46 | 45 | 12 | 41 | 132 | 0 | 5 | 3 | 0 | 0 | 2 | 3 | 3.18 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 84 | 0 | 6 | 2 | 2.45 | .273 | 1.13 | 5.3 | 4.9 | 7.6 | 113.2 | 67 | 35 | 31 | 12 | 61 | 95 | 0 | 8 | 3 | 0 | 0 | 0 | 1 | 4.32 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 43 | 0 | 1 | 0 | 2.61 | .260 | 0.97 | 6.2 | 2.6 | 8.1 | 48.1 | 33 | 16 | 14 | 5 | 14 | 43 | 0 | 4 | 0 | 0 | 0 | 4 | 4 | 3.69 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 40 | 0 | 1 | 2 | 8.17 | .370 | 1.71 | 12.8 | 2.8 | 4.0 | 36.1 | 51 | 35 | 33 | 11 | 11 | 16 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 7.17 |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 11 | 1 | 0 | 2 | 6.75 | .356 | 1.61 | 10.0 | 5.0 | 3.0 | 18.2 | 20 | 14 | 14 | 3 | 10 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.33 |