| SP | Scherzer, M.Scherzer, Max $$ >> | 33 | 2017 | R | 95 | 31 | 31 | 13 | 11 | 3.80 | .295 | 1.23 | 7.3 | 3.8 | 9.2 | 208.1 | 169 | 89 | 88 | 19 | 88 | 212 | 1 | 0 | 0 | 0 | 19 | 5 | 8 | 3.49 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 30 | 30 | 8 | 14 | 5.66 | .324 | 1.43 | 9.7 | 3.2 | 8.3 | 173.1 | 186 | 114 | 109 | 31 | 61 | 159 | 0 | 0 | 0 | 0 | 10 | 2 | 3 | 4.58 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 30 | 30 | 12 | 10 | 4.05 | .310 | 1.32 | 9.5 | 2.4 | 4.9 | 213.1 | 226 | 97 | 96 | 15 | 56 | 115 | 2 | 0 | 0 | 0 | 17 | 6 | 2 | 3.71 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 29 | 29 | 2 | 22 | 6.48 | .366 | 1.72 | 11.0 | 4.6 | 7.4 | 189.0 | 230 | 139 | 136 | 35 | 96 | 155 | 1 | 0 | 0 | 0 | 7 | 1 | 6 | 5.31 |
| SP | Ellsworth, D.Ellsworth, Dick >> | 23 | 1963 | L | 26 | 28 | 28 | 13 | 10 | 4.38 | .327 | 1.42 | 9.5 | 3.3 | 4.7 | 199.1 | 209 | 100 | 97 | 18 | 74 | 105 | 2 | 0 | 0 | 0 | 16 | 7 | 2 | 4.34 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 49 | 0 | 1 | 2 | 3.21 | .234 | 0.90 | 6.6 | 1.5 | 9.3 | 53.1 | 39 | 19 | 19 | 5 | 9 | 55 | 0 | 9 | 6 | 0 | 0 | 1 | 1 | 2.72 |
| CL | Hader, J.Hader, Josh † $$ >> | 24 | 2018 | L | 94 | 53 | 0 | 7 | 6 | 2.13 | .237 | 0.92 | 5.3 | 3.0 | 10.3 | 63.1 | 37 | 17 | 15 | 3 | 21 | 72 | 0 | 28 | 0 | 0 | 0 | 1 | 0 | 2.38 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 61 | 0 | 2 | 3 | 2.77 | .277 | 1.15 | 7.7 | 2.8 | 5.9 | 61.2 | 52 | 21 | 19 | 9 | 19 | 40 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.54 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 36 | 0 | 2 | 3 | 3.96 | .339 | 1.51 | 9.3 | 4.5 | 4.5 | 36.1 | 37 | 17 | 16 | 3 | 18 | 18 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.67 |