| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 36 | 36 | 16 | 10 | 3.54 | .275 | 1.12 | 7.8 | 2.4 | 9.6 | 241.1 | 208 | 107 | 95 | 33 | 63 | 257 | 1 | 0 | 0 | 0 | 22 | 3 | 0 | 3.47 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 33 | 33 | 11 | 10 | 4.56 | .336 | 1.49 | 10.3 | 3.1 | 8.1 | 213.0 | 243 | 120 | 108 | 27 | 74 | 192 | 1 | 0 | 0 | 0 | 18 | 6 | 4 | 3.97 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 78 | 33 | 33 | 11 | 15 | 5.45 | .340 | 1.52 | 11.1 | 2.5 | 6.0 | 216.1 | 267 | 149 | 131 | 38 | 61 | 143 | 4 | 0 | 0 | 0 | 15 | 7 | 9 | 4.91 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 71 | 31 | 31 | 12 | 11 | 5.82 | .349 | 1.58 | 11.2 | 3.0 | 5.1 | 196.1 | 244 | 136 | 127 | 26 | 66 | 110 | 3 | 0 | 0 | 0 | 12 | 6 | 7 | 4.70 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 71 | 0 | 5 | 11 | 3.54 | .287 | 1.17 | 7.4 | 3.2 | 10.1 | 73.2 | 60 | 35 | 29 | 8 | 26 | 82 | 0 | 36 | 4 | 0 | 0 | 3 | 3 | 3.37 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 84 | 0 | 3 | 5 | 2.99 | .305 | 1.29 | 7.3 | 4.4 | 9.0 | 93.1 | 75 | 34 | 31 | 9 | 45 | 93 | 0 | 5 | 4 | 0 | 0 | 3 | 0 | 3.81 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 84 | 0 | 6 | 7 | 3.02 | .285 | 1.19 | 6.7 | 4.1 | 6.9 | 101.1 | 75 | 44 | 34 | 9 | 46 | 77 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 4.00 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 56 | 0 | 1 | 1 | 1.78 | .304 | 1.29 | 6.1 | 5.7 | 10.5 | 55.2 | 37 | 14 | 11 | 3 | 35 | 64 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.35 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 41 | 0 | 2 | 2 | 5.72 | .335 | 1.49 | 10.6 | 2.9 | 9.4 | 50.1 | 59 | 35 | 32 | 9 | 16 | 52 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.28 |