| SP | Paddack, C.Paddack, Chris # >> | 23 | 2019 | R | 70 | 36 | 36 | 8 | 14 | 4.54 | .290 | 1.20 | 8.4 | 2.5 | 8.2 | 196.1 | 182 | 105 | 99 | 35 | 54 | 179 | 0 | 0 | 0 | 0 | 17 | 5 | 1 | 4.40 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 78 | 34 | 34 | 18 | 10 | 3.59 | .275 | 1.12 | 7.4 | 2.7 | 8.5 | 230.1 | 188 | 94 | 92 | 25 | 70 | 218 | 5 | 0 | 0 | 2 | 19 | 4 | 3 | 3.48 |
| SP | Pivetta, N.Pivetta, Nick # >> | 32 | 2025 | R | 72 | 33 | 33 | 8 | 14 | 4.94 | .322 | 1.40 | 9.4 | 3.3 | 7.4 | 196.2 | 204 | 109 | 108 | 33 | 71 | 162 | 0 | 0 | 0 | 0 | 14 | 5 | 3 | 4.70 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 73 | 31 | 31 | 11 | 10 | 3.43 | .306 | 1.30 | 7.5 | 4.3 | 8.6 | 188.2 | 156 | 78 | 72 | 13 | 89 | 180 | 0 | 0 | 0 | 0 | 18 | 5 | 12 | 3.48 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 97 | 87 | 0 | 10 | 2 | 4.76 | .287 | 1.18 | 6.2 | 4.5 | 9.8 | 111.2 | 77 | 60 | 59 | 16 | 55 | 121 | 0 | 8 | 6 | 0 | 0 | 3 | 2 | 4.26 |
| RP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 82 | 80 | 0 | 8 | 10 | 3.58 | .286 | 1.19 | 7.5 | 3.3 | 8.7 | 120.2 | 100 | 50 | 48 | 14 | 44 | 116 | 0 | 11 | 6 | 0 | 0 | 1 | 1 | 3.71 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 78 | 47 | 0 | 4 | 3 | 2.82 | .260 | 1.01 | 7.4 | 1.8 | 7.2 | 44.2 | 36 | 15 | 14 | 6 | 9 | 35 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 3.93 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 91 | 26 | 0 | 2 | 3 | 4.15 | .310 | 1.31 | 8.0 | 3.8 | 8.3 | 26.0 | 23 | 12 | 12 | 3 | 11 | 24 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.04 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 68 | 19 | 0 | 0 | 1 | 2.95 | .295 | 1.25 | 8.0 | 3.5 | 9.5 | 18.1 | 16 | 6 | 6 | 1 | 7 | 19 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 2.78 |