| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 32 | 32 | 8 | 14 | 4.12 | .315 | 1.35 | 8.6 | 3.6 | 4.8 | 212.0 | 202 | 97 | 97 | 22 | 84 | 114 | 6 | 0 | 0 | 2 | 15 | 6 | 5 | 4.55 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 9 | 7 | 3.92 | .338 | 1.52 | 9.2 | 4.4 | 8.8 | 158.1 | 162 | 75 | 69 | 12 | 78 | 155 | 0 | 0 | 0 | 0 | 11 | 3 | 7 | 3.56 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 32 | 31 | 11 | 14 | 4.44 | .310 | 1.33 | 9.2 | 2.8 | 4.9 | 184.2 | 189 | 101 | 91 | 22 | 57 | 101 | 0 | 0 | 1 | 0 | 13 | 3 | 6 | 4.43 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 29 | 29 | 8 | 12 | 4.36 | .313 | 1.34 | 8.6 | 3.5 | 4.3 | 173.1 | 165 | 87 | 84 | 19 | 67 | 83 | 5 | 0 | 0 | 3 | 15 | 5 | 1 | 4.72 |
| RP | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 95 | 71 | 0 | 9 | 4 | 3.93 | .268 | 1.08 | 7.6 | 2.3 | 7.9 | 75.2 | 63 | 33 | 33 | 13 | 19 | 66 | 0 | 8 | 5 | 0 | 0 | 1 | 0 | 4.29 |
| RP | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 44 | 75 | 0 | 4 | 1 | 3.95 | .328 | 1.43 | 8.8 | 4.2 | 5.2 | 54.2 | 53 | 26 | 24 | 4 | 25 | 31 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 4.31 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 64 | 0 | 7 | 1 | 2.69 | .269 | 1.09 | 6.7 | 3.1 | 4.8 | 67.0 | 50 | 21 | 20 | 8 | 23 | 36 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.55 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 39 | 0 | 5 | 1 | 4.56 | .349 | 1.56 | 9.0 | 5.2 | 6.3 | 47.1 | 47 | 24 | 24 | 7 | 27 | 33 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 5.38 |
| CL | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 64 | 0 | 1 | 7 | 2.36 | .309 | 1.31 | 6.0 | 6.0 | 8.9 | 68.2 | 45 | 19 | 18 | 4 | 45 | 67 | 0 | 24 | 4 | 0 | 0 | 2 | 0 | 3.87 |