| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 32 | 32 | 12 | 13 | 5.61 | .348 | 1.59 | 11.8 | 2.6 | 5.0 | 213.1 | 279 | 151 | 133 | 35 | 61 | 118 | 2 | 0 | 0 | 1 | 11 | 2 | 4 | 4.92 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 30 | 30 | 9 | 11 | 5.46 | .350 | 1.59 | 10.0 | 4.4 | 5.3 | 197.2 | 218 | 129 | 120 | 20 | 96 | 115 | 4 | 0 | 0 | 0 | 13 | 5 | 2 | 4.69 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 30 | 30 | 9 | 13 | 4.95 | .330 | 1.46 | 10.6 | 2.6 | 5.2 | 207.1 | 244 | 117 | 114 | 31 | 59 | 119 | 3 | 0 | 0 | 0 | 12 | 4 | 7 | 4.71 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 30 | 30 | 16 | 5 | 4.61 | .315 | 1.36 | 8.9 | 3.4 | 3.8 | 195.1 | 192 | 110 | 100 | 29 | 74 | 83 | 1 | 0 | 0 | 0 | 16 | 4 | 3 | 5.28 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 81 | 0 | 6 | 4 | 3.18 | .294 | 1.24 | 6.3 | 4.9 | 8.2 | 104.2 | 73 | 41 | 37 | 6 | 57 | 95 | 0 | 11 | 6 | 0 | 0 | 1 | 3 | 3.60 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 83 | 0 | 6 | 7 | 3.59 | .271 | 1.11 | 7.1 | 3.0 | 8.6 | 97.2 | 76 | 40 | 39 | 11 | 32 | 93 | 0 | 11 | 4 | 0 | 0 | 1 | 6 | 3.58 |
| RP | Soria, J.Soria, Joakim # >> | 24 | 2008 | R | 68 | 62 | 0 | 3 | 6 | 5.70 | .322 | 1.38 | 8.5 | 4.0 | 6.4 | 77.1 | 73 | 52 | 49 | 11 | 34 | 55 | 0 | 5 | 3 | 0 | 0 | 3 | 1 | 4.87 |
| RP | Messersmith, A.Messersmith, Andy † >> | 23 | 1968 | R | 57 | 49 | 0 | 6 | 3 | 4.87 | .334 | 1.49 | 7.4 | 6.2 | 5.7 | 77.2 | 63 | 45 | 42 | 7 | 53 | 49 | 0 | 2 | 2 | 0 | 0 | 1 | 2 | 5.01 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 2 | 2 | 1 | 1 | 2.87 | .230 | 0.89 | 7.8 | 0.6 | 6.0 | 15.2 | 13 | 5 | 5 | 1 | 1 | 10 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2.73 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 16 | 0 | 1 | 2 | 6.52 | .318 | 1.34 | 9.9 | 2.4 | 5.7 | 19.1 | 21 | 14 | 14 | 3 | 5 | 12 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.74 |