| SP | Koufax, S.Koufax, Sandy † # >> | 30 | 1965 | L | 98 | 33 | 33 | 19 | 9 | 3.49 | .284 | 1.16 | 7.6 | 2.8 | 8.0 | 250.0 | 211 | 105 | 97 | 26 | 79 | 221 | 10 | 0 | 0 | 2 | 21 | 8 | 6 | 3.63 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 32 | 32 | 14 | 12 | 3.77 | .288 | 1.19 | 7.7 | 3.0 | 4.4 | 229.1 | 197 | 101 | 96 | 19 | 77 | 112 | 6 | 0 | 0 | 2 | 18 | 4 | 0 | 4.16 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 31 | 31 | 11 | 14 | 5.57 | .343 | 1.54 | 9.5 | 4.4 | 4.9 | 171.1 | 180 | 109 | 106 | 23 | 84 | 93 | 2 | 0 | 0 | 1 | 15 | 4 | 7 | 5.20 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 28 | 28 | 10 | 12 | 4.64 | .307 | 1.31 | 8.4 | 3.4 | 5.6 | 196.0 | 183 | 119 | 101 | 22 | 74 | 122 | 10 | 0 | 0 | 0 | 13 | 4 | 4 | 4.41 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 85 | 0 | 3 | 5 | 3.89 | .291 | 1.20 | 8.1 | 2.8 | 10.1 | 106.1 | 95 | 48 | 46 | 14 | 33 | 119 | 0 | 9 | 6 | 0 | 0 | 3 | 1 | 3.49 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 73 | 0 | 4 | 7 | 3.67 | .252 | 0.99 | 7.2 | 1.7 | 8.2 | 103.0 | 82 | 42 | 42 | 15 | 20 | 94 | 0 | 8 | 3 | 0 | 0 | 2 | 1 | 3.71 |
| RP | Holland, G.Holland, Greg # >> | 27 | 2013 | R | 71 | 55 | 0 | 2 | 3 | 4.36 | .305 | 1.30 | 7.2 | 4.5 | 9.5 | 66.0 | 53 | 32 | 32 | 7 | 33 | 70 | 0 | 6 | 4 | 0 | 0 | 1 | 1 | 3.80 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 27 | 2 | 2 | 3 | 4.98 | .336 | 1.48 | 10.0 | 3.4 | 4.5 | 56.0 | 62 | 40 | 31 | 10 | 21 | 28 | 0 | 5 | 2 | 0 | 1 | 2 | 2 | 5.55 |